Preparation and in vitro-in vivo evaluation of Witepsol® H35 based self-nanoemulsifying drug delivery systems (SNEDDS) of coenzyme Q10

Pushp R. Nepal, Hyo Kyung Han, Hoo Kyun Choi

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

Coenzyme Q10 (CoQ10) was formulated into self-nanoemulsifying drug delivery systems (SNEDDS) to overcome low bioavailability attributed to hydrophobic nature of the drug. Screening of oil phase, surfactants and co-surfactants were performed to select Witepsol® H35, Solutol® HS15 and Lauroglycol® FCC, respectively. Ternary phase diagrams were drawn to identify nanoemulsifying region followed by optimization of SNEDDS formulation. The optimized formulation, CoQ10, Witepsol® H35, Solutol® HS15 and Lauroglycol® FCC in the weight ratio of 1:0.7:4:2, respectively, emulsified readily at 37 °C with mean emulsion droplet size of 32.4 nm. The stability test of the optimized formulation in pH 1.2 and 6.8 buffers confirmed no pH effect on emulsion droplet size. In vitro dissolution (emulsification) test and in vivo animal study of the formulation elucidated the complete emulsification of drug and improved oral bioavailability of poorly soluble CoQ10.

Original languageEnglish
Pages (from-to)224-232
Number of pages9
JournalEuropean Journal of Pharmaceutical Sciences
Volume39
Issue number4
DOIs
StatePublished - 19 Feb 2010

Keywords

  • Bioavailability
  • Coenzyme Q
  • Lauroglycol FCC
  • Self-nanoemulsifying drug delivery systems (SNEDDS)
  • Solutol HS15
  • Witepsol H35

Fingerprint

Dive into the research topics of 'Preparation and in vitro-in vivo evaluation of Witepsol® H35 based self-nanoemulsifying drug delivery systems (SNEDDS) of coenzyme Q10'. Together they form a unique fingerprint.

Cite this