Preparation of kanamycin powder by an optimized spray freeze-drying method

Jae Young Her, Chi Sung Song, Seung Ju Lee, Kwang Geun Lee

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The physical and antibiotic properties of kanamycin powders obtained by spray freeze drying (SFD) were compared with those of raw kanamycin. The SFD procedures were optimized to prepare kanamycin for use as an inhaled drug. Scanning electron microscopy (SEM) and a laser particle size analyzer were applied to estimate physical structure and properties of the particle. In addition, the disk diffusion method was used to compare the antibiotic activity of raw kanamycin and that produced by SFD. According to SEM, the kanamycin particles had various sizes and shapes with porous structures at different SFD conditions. The diameters of the kanamycin powders were between 13.5 μm and 21.8 μm, and their aerodynamic particle sizes were between 3.58 μm and 6.39 μm. The antibiotic activities of the raw and spray freeze-dried kanamycin samples were not significantly different (P > 0.05). The optimized conditions for annealing temperature, annealing time, kanamycin concentration, pressure, and nozzle tip lift were - 15 °C, 5 h, 10% kanamycin, 100 kPa, and, 1 mm, respectively.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalPowder Technology
Volume199
Issue number2
DOIs
StatePublished - 23 Apr 2010

Keywords

  • Inhaled drug
  • Kanamycin
  • Optimized method
  • Powder process
  • Spray freeze drying

Fingerprint

Dive into the research topics of 'Preparation of kanamycin powder by an optimized spray freeze-drying method'. Together they form a unique fingerprint.

Cite this