Progranulin and Breast Cancer Mortality: 13-Year Follow-Up of a Cohort Study

Dong Hoe Koo, Keun Seok Lee, Sung Hoon Sim, Heejung Chae, Eun Gyeong Lee, Jai Hong Han, So Youn Jung, Seeyoun Lee, Han Sung Kang, Eun Sook Lee, Cheol Young Park, Sang Woo Oh

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1 Scopus citations

Abstract

Background: We have reported that serum progranulin (PGRN) levels are clinically significant in predicting recurrence in patients with HR-positive breast cancer. The aim of the present study was to examine whether PGRN levels might be associated with breast cancer mortality. Methods: This was a cohort study of 695 newly diagnosed breast cancer patients who underwent curative surgery between 2001 and 2004. The relationship between breast cancer mortality and pre-operative serum PGRN levels in these patients with a median follow-up of 12.7 years was evaluated until May 2020. Results: A total of 118 (17%) deaths were identified in the cohort. According to the HR status, (10, 15, and 20)-year overall survival (OS) rates were (91.4, 81.1, and 75.9) % for HR-positive patients, and (76.5, 74.2, and 69.8) % for HR-negative patients, respectively (p = 0.003). Higher levels of PGRN were significantly associated with poor OS in the HR-positive group (p for trend = 0.001). In particular, hazard ratios for PGRN quartiles suggested a dose–response relationship, with the highest quartile having the worst OS in the HR-positive group (highest vs lowest: 15-year OS, (68.3 vs 90.0) %; 20-year OS, (62.3 vs 84.8) %, even after adjusting for age, tumor stage, and metabolic confounders. Conclusion: Pre-operative serum PGRN levels had clinical significance for predicting cancer mortality in breast cancer patients independent of tumor stage and metabolic parameters, especially in HR-positive tumors.

Original languageEnglish
Pages (from-to)251-261
Number of pages11
JournalBreast Cancer: Targets and Therapy
Volume15
DOIs
StatePublished - 2023

Keywords

  • breast cancer
  • long-term follow-up
  • mortality
  • progranulin

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