TY - JOUR
T1 - Quantification of the effect of Lipo-PGE1 on angiogenesis
AU - Eo, Surak
AU - Kwon, Chan
AU - Lee, Hyunjic
AU - Cho, Sanghun
AU - Kim, Jinyoung
AU - Baek, Goohyun
AU - Yeo, Jeongseok
AU - Lim, Chiyeon
N1 - Publisher Copyright:
© 2014 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Fifteen rabbits were used to assess the effect of Lipo-PGE1 on neovascularization. Merocel® and Alloderm® of the same size were implanted separately under the back skin to act as matrices for vessel growth. Lipo-PGE1 was injected intravenously for 2 weeks in an experimental group of eight rabbits, and they were compared with a control group of seven untreated animals. Blood flow was measured using the 99mTcO4- clearance technique. The mean blood clearance halftime (T1/2) and washout radioactivity were measured. Newly formed vessels were counted by CD31. The mean clearance halftime was 4005 ± 2161.3 and 13840 ± 4644.6 s in the experimental and control group, respectively, in the 1 × 2 × 1.5-cm-sized implants (p = 0.0125), and 1560 ± 1174.7 and 3405 ± 807.03 s, respectively, in the 2 × 2 × 1.5-cm-sized implants (p = 0.0413). Histological examinations revealed that the mean numbers of newly formed vessels in the experimental and control groups were 11 ± 1.58 and 7.8 ± 1.71, respectively, in the 1 × 2 × 1.5-cm-sized implants (p = 0.0501), and 20.19 ± 12.47 and 12.33 ± 3.25, respectively, in the 2 × 2 × 1.5-cm-sized implants (p = 0.02679). Lipo-PGE1 was found to be effective in promoting angiogenesis in a rabbit matrix model.
AB - Fifteen rabbits were used to assess the effect of Lipo-PGE1 on neovascularization. Merocel® and Alloderm® of the same size were implanted separately under the back skin to act as matrices for vessel growth. Lipo-PGE1 was injected intravenously for 2 weeks in an experimental group of eight rabbits, and they were compared with a control group of seven untreated animals. Blood flow was measured using the 99mTcO4- clearance technique. The mean blood clearance halftime (T1/2) and washout radioactivity were measured. Newly formed vessels were counted by CD31. The mean clearance halftime was 4005 ± 2161.3 and 13840 ± 4644.6 s in the experimental and control group, respectively, in the 1 × 2 × 1.5-cm-sized implants (p = 0.0125), and 1560 ± 1174.7 and 3405 ± 807.03 s, respectively, in the 2 × 2 × 1.5-cm-sized implants (p = 0.0413). Histological examinations revealed that the mean numbers of newly formed vessels in the experimental and control groups were 11 ± 1.58 and 7.8 ± 1.71, respectively, in the 1 × 2 × 1.5-cm-sized implants (p = 0.0501), and 20.19 ± 12.47 and 12.33 ± 3.25, respectively, in the 2 × 2 × 1.5-cm-sized implants (p = 0.02679). Lipo-PGE1 was found to be effective in promoting angiogenesis in a rabbit matrix model.
KW - Angiogenesis-inducing agents
KW - E1
KW - Lipo-PGE1
KW - Prostaglandin
KW - Vasodilators
UR - http://www.scopus.com/inward/record.url?scp=84919458709&partnerID=8YFLogxK
U2 - 10.1016/j.bjps.2014.09.035
DO - 10.1016/j.bjps.2014.09.035
M3 - Article
C2 - 25448364
AN - SCOPUS:84919458709
SN - 1748-6815
VL - 68
SP - 104
EP - 112
JO - Journal of Plastic, Reconstructive and Aesthetic Surgery
JF - Journal of Plastic, Reconstructive and Aesthetic Surgery
IS - 1
ER -