Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Jack Li Jie, Joe Nahra, Adam R. Johnson, Amy Bunker, Patrick O'Brien, Wen Song Yue, Daniel F. Ortwine, Chiu Fai Man, Vijay Baragi, Kenneth Kilgore, Richard D. Dyer, Hyo Kyung Han

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Pharmacology, Toxicology and Pharmaceutical Science