Radiation-induced cerebellar glioblastoma at the site of a treated medulloblastoma: Case report

Seung Yeob Yang, Kyu Chang Wang, Byung Kyu Cho, Young Yim Kim, Su Young Lim, Sung Hye Park, Han Kim Il, Seung Ki Kim

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Radiation-induced glioblastoma multiforme (GBM) is a rare complication of radiotherapy. The authors report such a case occurring 10 years after treatment of cerebellar medulloblastoma. The patient was a 15-year-old boy who had undergone a gross-total removal of a medulloblastoma and received radiation therapy at the age of 5 years. He had experienced no tumor recurrences for 10 years until a new enhancing mass was found at the original site of the medulloblastoma. Following its resection the new lesion was found to be a GBM and there was no evidence of a medulloblastoma. The second tumor developed at the same site as the previous one after a sufficient latent period and fulfilled the criteria for a radiation-induced neoplasm. The original tumor cells expressed synaptophysin without p53 overexpression, a characteristic feature of medulloblastomas. In contrast, cells from the later tumor expressed glial fibrillary acidic protein and p53 but not synaptophysin. A sequence analysis of the p53 gene showed deletion at codon 233 and a C to G transition at codon 278 in the GBM but no mutation in the medulloblastoma. A GBM specimen revealed no amplification of the epidermal growth factor receptor compared with a normal control specimen. In conclusion, the clinical features of a radiation-induced GBM are similar to that of the primary GBM, whereas its genetic alterations render it a secondary GBM. These findings indicate that radiation-induced GBM should be considered a distinct clinical entity.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalJournal of Neurosurgery
Volume102 PEDIATRICS
Issue numberSUPPL. 4
StatePublished - May 2005

Keywords

  • Glioblastoma multiforme
  • Medulloblastoma
  • p53 gene mutation
  • Pediatric neurosurgery
  • Radiation-induced neoplasm

Fingerprint

Dive into the research topics of 'Radiation-induced cerebellar glioblastoma at the site of a treated medulloblastoma: Case report'. Together they form a unique fingerprint.

Cite this