Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent

Tae Hyun Kim; Jun Young Lee; Min Kyu Kim; Jeong Hoon Park; Jae Min Oh

doi:10.1039/c6ra06256c

Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent

Tae Hyun Kim
, Jun Young Lee
, Min Kyu Kim
, Jeong Hoon Park
, Jae Min Oh

Department of Energy and Materials Engineering

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Radioisotope Co-57 was stably incorporated into a framework of layered double hydroxide nanoparticles through isomorphous substitution. An in vitro cellular uptake test resulted in ∼45 ID% high radioactivity delivering efficiency. In vivo biodistribution demonstrated time-dependent tumor accumulation of Co-57 by LDH showing high tumor-to-organ ratios.

Original language	English
Pages (from-to)	48415-48419
Number of pages	5
Journal	RSC Advances
Volume	6
Issue number	54
DOIs	https://doi.org/10.1039/c6ra06256c
State	Published - 2016

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10.1039/c6ra06256c

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title = "Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent",

abstract = "Radioisotope Co-57 was stably incorporated into a framework of layered double hydroxide nanoparticles through isomorphous substitution. An in vitro cellular uptake test resulted in ∼45 ID\% high radioactivity delivering efficiency. In vivo biodistribution demonstrated time-dependent tumor accumulation of Co-57 by LDH showing high tumor-to-organ ratios.",

author = "Kim, \{Tae Hyun\} and Lee, \{Jun Young\} and Kim, \{Min Kyu\} and Park, \{Jeong Hoon\} and Oh, \{Jae Min\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6ra06256c",

language = "English",

volume = "6",

pages = "48415--48419",

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issn = "2046-2069",

publisher = "Royal Society of Chemistry",

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T1 - Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent

AU - Kim, Tae Hyun

AU - Lee, Jun Young

AU - Kim, Min Kyu

AU - Park, Jeong Hoon

AU - Oh, Jae Min

PY - 2016

Y1 - 2016

N2 - Radioisotope Co-57 was stably incorporated into a framework of layered double hydroxide nanoparticles through isomorphous substitution. An in vitro cellular uptake test resulted in ∼45 ID% high radioactivity delivering efficiency. In vivo biodistribution demonstrated time-dependent tumor accumulation of Co-57 by LDH showing high tumor-to-organ ratios.

AB - Radioisotope Co-57 was stably incorporated into a framework of layered double hydroxide nanoparticles through isomorphous substitution. An in vitro cellular uptake test resulted in ∼45 ID% high radioactivity delivering efficiency. In vivo biodistribution demonstrated time-dependent tumor accumulation of Co-57 by LDH showing high tumor-to-organ ratios.

UR - https://www.scopus.com/pages/publications/84971324486

U2 - 10.1039/c6ra06256c

DO - 10.1039/c6ra06256c

M3 - Article

AN - SCOPUS:84971324486

SN - 2046-2069

VL - 6

SP - 48415

EP - 48419

JO - RSC Advances

JF - RSC Advances

IS - 54

ER -

Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent

Abstract

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