Regio- and stereoselective synthesis of truncated 3′- aminocarbanucleosides and their binding affinity at the A 3 adenosine receptor

Mun Ju Choi; Girish Chandra; Hyuk Woo Lee; Xiyan Hou; Won Jun Choi; Khai Phan; Kenneth A. Jacobson; Lak Shin Jeong

doi:10.1039/c1ob05853c

Regio- and stereoselective synthesis of truncated 3′- aminocarbanucleosides and their binding affinity at the A ₃ adenosine receptor

Mun Ju Choi
, Girish Chandra
, Hyuk Woo Lee
, Xiyan Hou
, Won Jun Choi
, Khai Phan
, Kenneth A. Jacobson
, Lak Shin Jeong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The stereoselective synthesis of truncated 3′-aminocarbanucleosides 4a-dvia a stereo- and regioselective conversion of a diol 9 to bromoacetate 11a and their binding affinity towards the human A ₃ adenosine receptor are described.

Original language	English
Pages (from-to)	6955-6962
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	20
DOIs	https://doi.org/10.1039/c1ob05853c
State	Published - 21 Oct 2011

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title = "Regio- and stereoselective synthesis of truncated 3′- aminocarbanucleosides and their binding affinity at the A 3 adenosine receptor",

abstract = "The stereoselective synthesis of truncated 3′-aminocarbanucleosides 4a-dvia a stereo- and regioselective conversion of a diol 9 to bromoacetate 11a and their binding affinity towards the human A 3 adenosine receptor are described.",

author = "Choi, \{Mun Ju\} and Girish Chandra and Lee, \{Hyuk Woo\} and Xiyan Hou and Choi, \{Won Jun\} and Khai Phan and Jacobson, \{Kenneth A.\} and Jeong, \{Lak Shin\}",

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T1 - Regio- and stereoselective synthesis of truncated 3′- aminocarbanucleosides and their binding affinity at the A 3 adenosine receptor

AU - Choi, Mun Ju

AU - Chandra, Girish

AU - Lee, Hyuk Woo

AU - Hou, Xiyan

AU - Choi, Won Jun

AU - Phan, Khai

AU - Jacobson, Kenneth A.

AU - Jeong, Lak Shin

PY - 2011/10/21

Y1 - 2011/10/21

N2 - The stereoselective synthesis of truncated 3′-aminocarbanucleosides 4a-dvia a stereo- and regioselective conversion of a diol 9 to bromoacetate 11a and their binding affinity towards the human A 3 adenosine receptor are described.

AB - The stereoselective synthesis of truncated 3′-aminocarbanucleosides 4a-dvia a stereo- and regioselective conversion of a diol 9 to bromoacetate 11a and their binding affinity towards the human A 3 adenosine receptor are described.

UR - https://www.scopus.com/pages/publications/80053312077

U2 - 10.1039/c1ob05853c

DO - 10.1039/c1ob05853c

M3 - Article

C2 - 21860878

AN - SCOPUS:80053312077

SN - 1477-0520

VL - 9

SP - 6955

EP - 6962

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 20

ER -

Regio- and stereoselective synthesis of truncated 3′- aminocarbanucleosides and their binding affinity at the A ₃ adenosine receptor

Abstract

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