Regulation of Nrf2-mediated phase ii detoxification and anti-oxidant genes

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations

Abstract

The molecular mechanisms by which a variety of naturally-occurring dietary compounds exert chemopreventive effects have been a subject of intense scientific investigations. Induction of phase II detoxification and anti-oxidant enzymes through activation of Nrf2/ ARE-dependent gene is recognized as one of the major cellular defense mechanisms against oxidative or xenobiotic stresses and currently represents a critical chemopreventive mechanism of action. In the present review, the functional significance of Keap1/ Nrf2 protein module in regulating ARE-dependent phase II detoxification and anti-oxidant gene expression is discussed. The biochemical mechanisms underlying the phosphorylation and expression of Keap1/Nrf2 proteins that are controlled by the intracellular signaling kinases and ubiquitin-mediated E3 ligase system as well as control of nucleocytoplasmic translocation of Nrf2 by its innate nuclear export signal (NES) are described.

Original languageEnglish
Pages (from-to)144-151
Number of pages8
JournalBiomolecules and Therapeutics
Volume20
Issue number2
DOIs
StatePublished - May 2012

Keywords

  • Antioxidant response element (ARE)
  • Chemoprevention
  • Kelch-like ECH-associated protein 1 (Keap1)
  • NF-E2-related factor-2 (Nrf2)

Fingerprint

Dive into the research topics of 'Regulation of Nrf2-mediated phase ii detoxification and anti-oxidant genes'. Together they form a unique fingerprint.

Cite this