Abstract
The molecular mechanisms by which a variety of naturally-occurring dietary compounds exert chemopreventive effects have been a subject of intense scientific investigations. Induction of phase II detoxification and anti-oxidant enzymes through activation of Nrf2/ ARE-dependent gene is recognized as one of the major cellular defense mechanisms against oxidative or xenobiotic stresses and currently represents a critical chemopreventive mechanism of action. In the present review, the functional significance of Keap1/ Nrf2 protein module in regulating ARE-dependent phase II detoxification and anti-oxidant gene expression is discussed. The biochemical mechanisms underlying the phosphorylation and expression of Keap1/Nrf2 proteins that are controlled by the intracellular signaling kinases and ubiquitin-mediated E3 ligase system as well as control of nucleocytoplasmic translocation of Nrf2 by its innate nuclear export signal (NES) are described.
Original language | English |
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Pages (from-to) | 144-151 |
Number of pages | 8 |
Journal | Biomolecules and Therapeutics |
Volume | 20 |
Issue number | 2 |
DOIs | |
State | Published - May 2012 |
Keywords
- Antioxidant response element (ARE)
- Chemoprevention
- Kelch-like ECH-associated protein 1 (Keap1)
- NF-E2-related factor-2 (Nrf2)