TY - JOUR
T1 - Regulation of the Intracellular ROS Level Is Critical for the Antiproliferative Effect of Quercetin in the Hepatocellular Carcinoma Cell Line HepG2
AU - Jeon, Ji Sook
AU - Kwon, Sora
AU - Ban, Kiwon
AU - Kwon Hong, Young
AU - Ahn, Curie
AU - Sung, Jung Suk
AU - Choi, Inho
N1 - Publisher Copyright:
© 2019, © 2019 Taylor & Francis Group, LLC.
PY - 2019/7/4
Y1 - 2019/7/4
N2 - Quercetin, an antioxidant flavonoid, has been known that it can induce the cell cycle arrest and apoptosis of hepatocellular carcinoma (HCC) cells by the stabilization or induction of p53. Here, we found that quercetin reduced the proliferation of HepG2 cells significantly, but not Huh7 cells. Interestingly, quercetin down-regulated the intracellular ROS level in HepG2 cells, but not Huh7 cells. Functional study using siRNA showed that the proliferation of HepG2 cells was still regulated by quercetin in the absence of p53. Furthermore, we confirmed the effect of quercetin on HepG2 cells by H 2 O 2 supplementation. This study demonstrates that the antiproliferative effect of quercetin on HCC cells can be mediated by reducing intracellular ROS, which is independent of p53 expression.
AB - Quercetin, an antioxidant flavonoid, has been known that it can induce the cell cycle arrest and apoptosis of hepatocellular carcinoma (HCC) cells by the stabilization or induction of p53. Here, we found that quercetin reduced the proliferation of HepG2 cells significantly, but not Huh7 cells. Interestingly, quercetin down-regulated the intracellular ROS level in HepG2 cells, but not Huh7 cells. Functional study using siRNA showed that the proliferation of HepG2 cells was still regulated by quercetin in the absence of p53. Furthermore, we confirmed the effect of quercetin on HepG2 cells by H 2 O 2 supplementation. This study demonstrates that the antiproliferative effect of quercetin on HCC cells can be mediated by reducing intracellular ROS, which is independent of p53 expression.
UR - http://www.scopus.com/inward/record.url?scp=85060334796&partnerID=8YFLogxK
U2 - 10.1080/01635581.2018.1559929
DO - 10.1080/01635581.2018.1559929
M3 - Article
C2 - 30661409
AN - SCOPUS:85060334796
SN - 0163-5581
VL - 71
SP - 861
EP - 869
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 5
ER -