Abstract
Tauroursodeoxycholic acid (TUDCA) has a role in the regulation of the differentiation of mesenchymal stem cells. In this study, TUDCA was demonstrated to increase osteogenic differentiation at a low concentration (25 μM) and chondrogenic differentiation at a high concentration (2500 μM). We investigated the regeneration of osteochondral defects in a rat model using a bilayer plug loaded with two different concentration of TUDCA-PLGA microspheres (TUDCA-MS bilayer plug). The TUDCA-MS bilayer plug successfully regenerated cartilage and subchondral bone layer. Therefore, we suggest that the TUDCA-MS bilayer plug as a new treatment method for simultaneous regeneration of cartilage and subchondral bone layer.
Original language | English |
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Pages (from-to) | 295-303 |
Number of pages | 9 |
Journal | Journal of Industrial and Engineering Chemistry |
Volume | 61 |
DOIs | |
State | Published - 25 May 2018 |
Keywords
- Bi-layered hydrogel
- Microsphere
- Osteoarthritis
- Stem cell differentiation
- Tauroursodeoxycholic acid