Restoration of articular osteochondral defects in rat by a bi-layered hyaluronic acid hydrogel plug with TUDCA-PLGA microsphere

Byoung Ju Kim, Yoshie Arai, Bogyu Choi, Sunghyun Park, Jinsung Ahn, In Bo Han, Soo Hong Lee

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Tauroursodeoxycholic acid (TUDCA) has a role in the regulation of the differentiation of mesenchymal stem cells. In this study, TUDCA was demonstrated to increase osteogenic differentiation at a low concentration (25 μM) and chondrogenic differentiation at a high concentration (2500 μM). We investigated the regeneration of osteochondral defects in a rat model using a bilayer plug loaded with two different concentration of TUDCA-PLGA microspheres (TUDCA-MS bilayer plug). The TUDCA-MS bilayer plug successfully regenerated cartilage and subchondral bone layer. Therefore, we suggest that the TUDCA-MS bilayer plug as a new treatment method for simultaneous regeneration of cartilage and subchondral bone layer.

Original languageEnglish
Pages (from-to)295-303
Number of pages9
JournalJournal of Industrial and Engineering Chemistry
Volume61
DOIs
StatePublished - 25 May 2018

Keywords

  • Bi-layered hydrogel
  • Microsphere
  • Osteoarthritis
  • Stem cell differentiation
  • Tauroursodeoxycholic acid

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