Restoration of articular osteochondral defects in rat by a bi-layered hyaluronic acid hydrogel plug with TUDCA-PLGA microsphere

Byoung Ju Kim; Yoshie Arai; Bogyu Choi; Sunghyun Park; Jinsung Ahn; In Bo Han; Soo Hong Lee

doi:10.1016/j.jiec.2017.12.027

Restoration of articular osteochondral defects in rat by a bi-layered hyaluronic acid hydrogel plug with TUDCA-PLGA microsphere

Byoung Ju Kim
, Yoshie Arai
, Bogyu Choi
, Sunghyun Park
, Jinsung Ahn
, In Bo Han
, Soo Hong Lee

Department of Biomedical Engineering

CHA University

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Tauroursodeoxycholic acid (TUDCA) has a role in the regulation of the differentiation of mesenchymal stem cells. In this study, TUDCA was demonstrated to increase osteogenic differentiation at a low concentration (25 μM) and chondrogenic differentiation at a high concentration (2500 μM). We investigated the regeneration of osteochondral defects in a rat model using a bilayer plug loaded with two different concentration of TUDCA-PLGA microspheres (TUDCA-MS bilayer plug). The TUDCA-MS bilayer plug successfully regenerated cartilage and subchondral bone layer. Therefore, we suggest that the TUDCA-MS bilayer plug as a new treatment method for simultaneous regeneration of cartilage and subchondral bone layer.

Original language	English
Pages (from-to)	295-303
Number of pages	9
Journal	Journal of Industrial and Engineering Chemistry
Volume	61
DOIs	https://doi.org/10.1016/j.jiec.2017.12.027
State	Published - 25 May 2018

Keywords

Bi-layered hydrogel
Microsphere
Osteoarthritis
Stem cell differentiation
Tauroursodeoxycholic acid

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10.1016/j.jiec.2017.12.027

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title = "Restoration of articular osteochondral defects in rat by a bi-layered hyaluronic acid hydrogel plug with TUDCA-PLGA microsphere",

abstract = "Tauroursodeoxycholic acid (TUDCA) has a role in the regulation of the differentiation of mesenchymal stem cells. In this study, TUDCA was demonstrated to increase osteogenic differentiation at a low concentration (25 μM) and chondrogenic differentiation at a high concentration (2500 μM). We investigated the regeneration of osteochondral defects in a rat model using a bilayer plug loaded with two different concentration of TUDCA-PLGA microspheres (TUDCA-MS bilayer plug). The TUDCA-MS bilayer plug successfully regenerated cartilage and subchondral bone layer. Therefore, we suggest that the TUDCA-MS bilayer plug as a new treatment method for simultaneous regeneration of cartilage and subchondral bone layer.",

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author = "Kim, \{Byoung Ju\} and Yoshie Arai and Bogyu Choi and Sunghyun Park and Jinsung Ahn and Han, \{In Bo\} and Lee, \{Soo Hong\}",

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month = may,

day = "25",

doi = "10.1016/j.jiec.2017.12.027",

language = "English",

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journal = "Journal of Industrial and Engineering Chemistry",

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T1 - Restoration of articular osteochondral defects in rat by a bi-layered hyaluronic acid hydrogel plug with TUDCA-PLGA microsphere

AU - Kim, Byoung Ju

AU - Arai, Yoshie

AU - Choi, Bogyu

AU - Park, Sunghyun

AU - Ahn, Jinsung

AU - Han, In Bo

AU - Lee, Soo Hong

PY - 2018/5/25

Y1 - 2018/5/25

N2 - Tauroursodeoxycholic acid (TUDCA) has a role in the regulation of the differentiation of mesenchymal stem cells. In this study, TUDCA was demonstrated to increase osteogenic differentiation at a low concentration (25 μM) and chondrogenic differentiation at a high concentration (2500 μM). We investigated the regeneration of osteochondral defects in a rat model using a bilayer plug loaded with two different concentration of TUDCA-PLGA microspheres (TUDCA-MS bilayer plug). The TUDCA-MS bilayer plug successfully regenerated cartilage and subchondral bone layer. Therefore, we suggest that the TUDCA-MS bilayer plug as a new treatment method for simultaneous regeneration of cartilage and subchondral bone layer.

AB - Tauroursodeoxycholic acid (TUDCA) has a role in the regulation of the differentiation of mesenchymal stem cells. In this study, TUDCA was demonstrated to increase osteogenic differentiation at a low concentration (25 μM) and chondrogenic differentiation at a high concentration (2500 μM). We investigated the regeneration of osteochondral defects in a rat model using a bilayer plug loaded with two different concentration of TUDCA-PLGA microspheres (TUDCA-MS bilayer plug). The TUDCA-MS bilayer plug successfully regenerated cartilage and subchondral bone layer. Therefore, we suggest that the TUDCA-MS bilayer plug as a new treatment method for simultaneous regeneration of cartilage and subchondral bone layer.

KW - Bi-layered hydrogel

KW - Microsphere

KW - Osteoarthritis

KW - Stem cell differentiation

KW - Tauroursodeoxycholic acid

UR - https://www.scopus.com/pages/publications/85039746391

U2 - 10.1016/j.jiec.2017.12.027

DO - 10.1016/j.jiec.2017.12.027

M3 - Article

AN - SCOPUS:85039746391

SN - 1226-086X

VL - 61

SP - 295

EP - 303

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Restoration of articular osteochondral defects in rat by a bi-layered hyaluronic acid hydrogel plug with TUDCA-PLGA microsphere

Abstract

Keywords

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