TY - JOUR
T1 - Revisiting of Pd Nanoparticles in Cancer Treatment
T2 - All-Round Excellence of Porous Pd Nanoplates in Gene-Thermo Combinational Therapy
AU - Kang, Seounghun
AU - Shin, Woojun
AU - Kang, Kyunglee
AU - Choi, Myung Ho
AU - Kim, Young Jin
AU - Kim, Young Kwan
AU - Min, Dal Hee
AU - Jang, Hongje
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/4/25
Y1 - 2018/4/25
N2 - Gold nanomaterials are commonly used in biomedical applications owing to their excellent biocompatibility and unique physicochemical and optical properties, whereas Pd nanomaterials are mainly used as catalysts. Here, we re-examined the possible applications of Pd nanomaterials. Reducing agent-assisted excessive galvanic replacement-mediated porous Au nanoplates, porous Pt nanoplates, and porous Pd nanoplate synthesis enabled us to compare the properties and efficiency of nanoplates composed of three metal elements (Au, Pt, and Pd). According to our analytical results, porous Pd nanoplates exhibited exceptional all-round excellence in photothermal conversion, therapeutic gene loading/releasing, cytotoxicity, and in vitro combination cancer treatment. We believe that this discovery broadens the potential applications of metal nanomaterials, with an emphasis on more efficient biomedical applications in limited conventional fields.
AB - Gold nanomaterials are commonly used in biomedical applications owing to their excellent biocompatibility and unique physicochemical and optical properties, whereas Pd nanomaterials are mainly used as catalysts. Here, we re-examined the possible applications of Pd nanomaterials. Reducing agent-assisted excessive galvanic replacement-mediated porous Au nanoplates, porous Pt nanoplates, and porous Pd nanoplate synthesis enabled us to compare the properties and efficiency of nanoplates composed of three metal elements (Au, Pt, and Pd). According to our analytical results, porous Pd nanoplates exhibited exceptional all-round excellence in photothermal conversion, therapeutic gene loading/releasing, cytotoxicity, and in vitro combination cancer treatment. We believe that this discovery broadens the potential applications of metal nanomaterials, with an emphasis on more efficient biomedical applications in limited conventional fields.
KW - cancer therapy
KW - drug delivery
KW - galvanic replacement
KW - noble metal
KW - photothermal conversion
UR - http://www.scopus.com/inward/record.url?scp=85045946076&partnerID=8YFLogxK
U2 - 10.1021/acsami.8b01000
DO - 10.1021/acsami.8b01000
M3 - Article
C2 - 29608263
AN - SCOPUS:85045946076
SN - 1944-8244
VL - 10
SP - 13819
EP - 13828
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 16
ER -