Revisiting of Pd Nanoparticles in Cancer Treatment: All-Round Excellence of Porous Pd Nanoplates in Gene-Thermo Combinational Therapy

Seounghun Kang, Woojun Shin, Kyunglee Kang, Myung Ho Choi, Young Jin Kim, Young Kwan Kim, Dal Hee Min, Hongje Jang

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Gold nanomaterials are commonly used in biomedical applications owing to their excellent biocompatibility and unique physicochemical and optical properties, whereas Pd nanomaterials are mainly used as catalysts. Here, we re-examined the possible applications of Pd nanomaterials. Reducing agent-assisted excessive galvanic replacement-mediated porous Au nanoplates, porous Pt nanoplates, and porous Pd nanoplate synthesis enabled us to compare the properties and efficiency of nanoplates composed of three metal elements (Au, Pt, and Pd). According to our analytical results, porous Pd nanoplates exhibited exceptional all-round excellence in photothermal conversion, therapeutic gene loading/releasing, cytotoxicity, and in vitro combination cancer treatment. We believe that this discovery broadens the potential applications of metal nanomaterials, with an emphasis on more efficient biomedical applications in limited conventional fields.

Original languageEnglish
Pages (from-to)13819-13828
Number of pages10
JournalACS Applied Materials and Interfaces
Volume10
Issue number16
DOIs
StatePublished - 25 Apr 2018

Keywords

  • cancer therapy
  • drug delivery
  • galvanic replacement
  • noble metal
  • photothermal conversion

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