Rice bran ash mineral extract increases pigmentation through the p-ERK pathway in zebrafish (Danio rerio)

Yu Mi Kim; Eun Cheol Lee; Han Moi Lim; Young Kwon Seo

doi:10.3390/ijms20092172

Rice bran ash mineral extract increases pigmentation through the p-ERK pathway in zebrafish (Danio rerio)

Yu Mi Kim, Eun Cheol Lee, Han Moi Lim, Young Kwon Seo

Department of Biomedical Engineering

Dongguk University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The purpose of the present study is to evaluate the effect of rice bran ash mineral extract (RBM) on pigmentation in zebrafish (Danio rerio). Melanin has the ability to block ultraviolet (UV) radiation and scavenge free oxygen radicals, thus protecting the skin from their harmful effects. Agents that increase melanin synthesis in melanocytes may reduce the risk of photodamage and skin cancer. The present study investigates the effect of RBM on pigmentation in zebrafish and the underlying mechanism. RBM was found to significantly increase the expression of microphthalmia-associated transcription factor (MITF), a key transcription factor involved in melanin production. RBM also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), which negatively regulates zebrafish pigmentation. Together, these results suggest that RBM promotes melanin biosynthesis in zebrafish.

Original language	English
Article number	2172
Journal	International Journal of Molecular Sciences
Volume	20
Issue number	9
DOIs	https://doi.org/10.3390/ijms20092172
State	Published - 1 May 2019

Keywords

Melanogenesis
p-ERK signaling pathway
Pigmentation
Zebrafish

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms20092172

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title = "Rice bran ash mineral extract increases pigmentation through the p-ERK pathway in zebrafish (Danio rerio)",

abstract = "The purpose of the present study is to evaluate the effect of rice bran ash mineral extract (RBM) on pigmentation in zebrafish (Danio rerio). Melanin has the ability to block ultraviolet (UV) radiation and scavenge free oxygen radicals, thus protecting the skin from their harmful effects. Agents that increase melanin synthesis in melanocytes may reduce the risk of photodamage and skin cancer. The present study investigates the effect of RBM on pigmentation in zebrafish and the underlying mechanism. RBM was found to significantly increase the expression of microphthalmia-associated transcription factor (MITF), a key transcription factor involved in melanin production. RBM also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), which negatively regulates zebrafish pigmentation. Together, these results suggest that RBM promotes melanin biosynthesis in zebrafish.",

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author = "Kim, {Yu Mi} and Lee, {Eun Cheol} and Lim, {Han Moi} and Seo, {Young Kwon}",

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AU - Lee, Eun Cheol

AU - Lim, Han Moi

AU - Seo, Young Kwon

PY - 2019/5/1

Y1 - 2019/5/1

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AB - The purpose of the present study is to evaluate the effect of rice bran ash mineral extract (RBM) on pigmentation in zebrafish (Danio rerio). Melanin has the ability to block ultraviolet (UV) radiation and scavenge free oxygen radicals, thus protecting the skin from their harmful effects. Agents that increase melanin synthesis in melanocytes may reduce the risk of photodamage and skin cancer. The present study investigates the effect of RBM on pigmentation in zebrafish and the underlying mechanism. RBM was found to significantly increase the expression of microphthalmia-associated transcription factor (MITF), a key transcription factor involved in melanin production. RBM also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), which negatively regulates zebrafish pigmentation. Together, these results suggest that RBM promotes melanin biosynthesis in zebrafish.

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KW - p-ERK signaling pathway

KW - Pigmentation

KW - Zebrafish

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Rice bran ash mineral extract increases pigmentation through the p-ERK pathway in zebrafish (Danio rerio)

Abstract

Keywords

UN SDGs

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