TY - JOUR
T1 - Risk factors for recurrence of vaginal intraepithelial neoplasia in the vaginal vault after laser vaporization
AU - Kim, Hee Seung
AU - Park, Noh Hyun
AU - Park, In Ae
AU - Park, Ju Hee
AU - Chung, Hyun Hoon
AU - Kim, Jae Weon
AU - Song, Yong Sang
AU - Kang, Soon Beom
PY - 2009/3
Y1 - 2009/3
N2 - We sought to investigate risk factors for recurrence of vaginal intraepithelial neoplasia (VAIN) in the vaginal vault after laser vaporization. Materials and Methods: Among 162 patients treated with laser vaporization in the vaginal vault after hysterectomy between March 1998 and August 2007, the clinical data of 68 patients were reviewed retrospectively. They underwent hysterectomy before laser vaporization due to the International Federation of Gynecology and Obstetrics (FIGO) stage Ial-Ibl cervical cancer (n = 17), cervical carcinoma in situ (CIS, n-18), cervical intraepithelial neoplasia (CIN) (CIN I, n = 4; CINII, n = 9; CIN III, n = 12), leiomyoma (n - 5) and endometrial polyp (n - 3). All patients were diagnosed as VAIN I (n = 24), VAIN II (n = 18) and VAIN III (n = 26) in the vaginal vault before laser vaporization. Risk factors for recurrence of VAIN in the vaginal vault after laser vaporization were investigated by multivariate logistic regression analysis. Results: The median age was 48 years (range, 32-74 years), and the median duration of follow-up was 33 months (range, 10-115 months). Among all patients, 18 (26.5%) showed disease recurrence. Age (≤48 years) and VAIN III in the vaginal vault before laser vaporization were risk factors for recurrence after laser vaporization (age ≤48 years, adjusted OR, 2.07, 95% CI, 1.18-7.01; VAIN III in the vaginal vault before laser vaporization, adjusted OR, 8.42, 95% CI, 1.63-18.56). Conclusion: Laser vaporization may be a feasible method for the treatment of VAIN in the vaginal vault after hysterectomy. However, age (≤48 years) and VAIN III in the vaginal vault before laser vaporization should be considered as risk factors for recurrence after laser vaporization. Lasers Surg. Med. 41:196-202, 2009.
AB - We sought to investigate risk factors for recurrence of vaginal intraepithelial neoplasia (VAIN) in the vaginal vault after laser vaporization. Materials and Methods: Among 162 patients treated with laser vaporization in the vaginal vault after hysterectomy between March 1998 and August 2007, the clinical data of 68 patients were reviewed retrospectively. They underwent hysterectomy before laser vaporization due to the International Federation of Gynecology and Obstetrics (FIGO) stage Ial-Ibl cervical cancer (n = 17), cervical carcinoma in situ (CIS, n-18), cervical intraepithelial neoplasia (CIN) (CIN I, n = 4; CINII, n = 9; CIN III, n = 12), leiomyoma (n - 5) and endometrial polyp (n - 3). All patients were diagnosed as VAIN I (n = 24), VAIN II (n = 18) and VAIN III (n = 26) in the vaginal vault before laser vaporization. Risk factors for recurrence of VAIN in the vaginal vault after laser vaporization were investigated by multivariate logistic regression analysis. Results: The median age was 48 years (range, 32-74 years), and the median duration of follow-up was 33 months (range, 10-115 months). Among all patients, 18 (26.5%) showed disease recurrence. Age (≤48 years) and VAIN III in the vaginal vault before laser vaporization were risk factors for recurrence after laser vaporization (age ≤48 years, adjusted OR, 2.07, 95% CI, 1.18-7.01; VAIN III in the vaginal vault before laser vaporization, adjusted OR, 8.42, 95% CI, 1.63-18.56). Conclusion: Laser vaporization may be a feasible method for the treatment of VAIN in the vaginal vault after hysterectomy. However, age (≤48 years) and VAIN III in the vaginal vault before laser vaporization should be considered as risk factors for recurrence after laser vaporization. Lasers Surg. Med. 41:196-202, 2009.
KW - Laser vaporization
KW - Recurrence
KW - Vaginal intraepithelial neoplasia
KW - Vaginal vault
UR - http://www.scopus.com/inward/record.url?scp=64849114205&partnerID=8YFLogxK
U2 - 10.1002/lsm.20741
DO - 10.1002/lsm.20741
M3 - Article
C2 - 19291750
AN - SCOPUS:64849114205
SN - 0196-8092
VL - 41
SP - 196
EP - 202
JO - Lasers in Surgery and Medicine
JF - Lasers in Surgery and Medicine
IS - 3
ER -