TY - JOUR
T1 - Risk of cancer among patients with depressive disorder
T2 - a meta-analysis and implications
AU - Ahn, Hee Kyung
AU - Bae, Jeong Hun
AU - Ahn, Hong Yup
AU - Hwang, In Cheol
N1 - Publisher Copyright:
Copyright © 2016 John Wiley & Sons, Ltd.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Objective: The question of cancer risk in individuals with depression is unclear, primarily because of the heterogeneity of the assessment of depression in the published literature. To clarify the mixed findings, this analysis was limited to articles that used a reliable method of ascertaining depressive disorder. Methods: We searched PubMed, EMBASE, and the Cochrane Library to identify studies investigating the effect of depression on subsequent risk of cancer, defining depression based on the criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and/or the International Classification of Disease (ICD). We calculated a pooled odds ratio (OR) for developing cancer with the 95% confidence interval (CI). Results: Nine studies fulfilled the eligibility criteria. In a random-effects model, patients with depressive disorder were at increased risk for cancer (OR, 1.26; 95% CI, 1.06–1.50, P = 0.01). However, a significant effect was observed only in low-quality studies (OR, 1.31; 95% CI, 1.05–1.63, P = 0.018), and not in high-quality studies (OR, 1.15; 95% CI, 0.85–1.56, P = 0.366). Conclusion: Our results did not demonstrate that people with depressive disorder are at increased risk for developing cancer. Well-designed prospective studies of recurrent or persistent depressive disorder that control for lifestyle factors including smoking are warranted.
AB - Objective: The question of cancer risk in individuals with depression is unclear, primarily because of the heterogeneity of the assessment of depression in the published literature. To clarify the mixed findings, this analysis was limited to articles that used a reliable method of ascertaining depressive disorder. Methods: We searched PubMed, EMBASE, and the Cochrane Library to identify studies investigating the effect of depression on subsequent risk of cancer, defining depression based on the criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM) and/or the International Classification of Disease (ICD). We calculated a pooled odds ratio (OR) for developing cancer with the 95% confidence interval (CI). Results: Nine studies fulfilled the eligibility criteria. In a random-effects model, patients with depressive disorder were at increased risk for cancer (OR, 1.26; 95% CI, 1.06–1.50, P = 0.01). However, a significant effect was observed only in low-quality studies (OR, 1.31; 95% CI, 1.05–1.63, P = 0.018), and not in high-quality studies (OR, 1.15; 95% CI, 0.85–1.56, P = 0.366). Conclusion: Our results did not demonstrate that people with depressive disorder are at increased risk for developing cancer. Well-designed prospective studies of recurrent or persistent depressive disorder that control for lifestyle factors including smoking are warranted.
UR - http://www.scopus.com/inward/record.url?scp=84957989765&partnerID=8YFLogxK
U2 - 10.1002/pon.4084
DO - 10.1002/pon.4084
M3 - Review article
C2 - 26810736
AN - SCOPUS:84957989765
SN - 1057-9249
VL - 25
SP - 1393
EP - 1399
JO - Psycho-Oncology
JF - Psycho-Oncology
IS - 12
ER -