Robust Association Tests for the Replication of Genome-Wide Association Studies

Jungnam Joo; Ju Hyun Park; Bora Lee; Boram Park; Sohee Kim; Kyong Ah Yoon; Jin Soo Lee; Nancy L. Geller

doi:10.1155/2015/461593

Robust Association Tests for the Replication of Genome-Wide Association Studies

Jungnam Joo, Ju Hyun Park, Bora Lee, Boram Park, Sohee Kim, Kyong Ah Yoon, Jin Soo Lee, Nancy L. Geller

Department of Statistics

Research output: Contribution to journal › Article › peer-review

Abstract

In genome-wide association study (GWAS), robust genetic association tests such as maximum of three CATTs (MAX3), each corresponding to recessive, additive, and dominant genetic models, the minimum p value of Pearson's Chi-square test with 2 degrees of freedom, and CATT based on additive genetic model (MIN2), genetic model selection (GMS), and genetic model exclusion (GME) methods have been shown to provide better power performance under wide range of underlying genetic models. In this paper, we demonstrate how these robust tests can be applied to the replication study of GWAS and how the overall statistical significance can be evaluated using the combined test formed by p values of the discovery and replication studies.

Original language	English
Article number	461593
Journal	BioMed Research International
Volume	2015
DOIs	https://doi.org/10.1155/2015/461593
State	Published - 2015

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abstract = "In genome-wide association study (GWAS), robust genetic association tests such as maximum of three CATTs (MAX3), each corresponding to recessive, additive, and dominant genetic models, the minimum p value of Pearson's Chi-square test with 2 degrees of freedom, and CATT based on additive genetic model (MIN2), genetic model selection (GMS), and genetic model exclusion (GME) methods have been shown to provide better power performance under wide range of underlying genetic models. In this paper, we demonstrate how these robust tests can be applied to the replication study of GWAS and how the overall statistical significance can be evaluated using the combined test formed by p values of the discovery and replication studies.",

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AU - Kim, Sohee

AU - Yoon, Kyong Ah

AU - Lee, Jin Soo

AU - Geller, Nancy L.

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Robust Association Tests for the Replication of Genome-Wide Association Studies

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