Role of phytochemicals in the modulation of miRNA expression in cancer

Trishna Debnath; Narayan Chandra Deb Nath; Eun Kyung Kim; Kwang Geun Lee

doi:10.1039/c7fo00739f

Role of phytochemicals in the modulation of miRNA expression in cancer

Trishna Debnath
, Narayan Chandra Deb Nath
, Eun Kyung Kim
, Kwang Geun Lee

Department of Food Science & Biotechnology

Dongguk University
Konkuk University

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

MicroRNAs (miRNAs) are single-stranded non-coding endogenous RNAs linked with normal developmental and physiological processes. Recent studies have demonstrated that the dysregulation of miRNAs plays an important role in the beginning, progression, and metastasis of many cancers. Additionally, they are involved in the regulation of the epithelial-to-mesenchymal transition (EMT) in many cancer cells. Several studies have suggested that phytochemicals play an important role in the modulation of miRNA expression, which is related to changes in oncogenes, tumour suppressors, and cancer-related protein expression. Hence, phytonutrients can suppress tumour development, prevent metastasis, reverse the EMT, and improve drug sensitivity via the modulation of miRNA expression. In this review, we discuss tumour-suppressing and oncogenic miRNAs and the mechanism of action for miRNAs as well as the role of phytochemicals in the modulation of miRNAs in various cancer cells.

Original language	English
Pages (from-to)	3432-3442
Number of pages	11
Journal	Food and Function
Volume	8
Issue number	10
DOIs	https://doi.org/10.1039/c7fo00739f
State	Published - Oct 2017

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Cite this

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title = "Role of phytochemicals in the modulation of miRNA expression in cancer",

abstract = "MicroRNAs (miRNAs) are single-stranded non-coding endogenous RNAs linked with normal developmental and physiological processes. Recent studies have demonstrated that the dysregulation of miRNAs plays an important role in the beginning, progression, and metastasis of many cancers. Additionally, they are involved in the regulation of the epithelial-to-mesenchymal transition (EMT) in many cancer cells. Several studies have suggested that phytochemicals play an important role in the modulation of miRNA expression, which is related to changes in oncogenes, tumour suppressors, and cancer-related protein expression. Hence, phytonutrients can suppress tumour development, prevent metastasis, reverse the EMT, and improve drug sensitivity via the modulation of miRNA expression. In this review, we discuss tumour-suppressing and oncogenic miRNAs and the mechanism of action for miRNAs as well as the role of phytochemicals in the modulation of miRNAs in various cancer cells.",

author = "Trishna Debnath and \{Deb Nath\}, \{Narayan Chandra\} and Kim, \{Eun Kyung\} and Lee, \{Kwang Geun\}",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

month = oct,

doi = "10.1039/c7fo00739f",

language = "English",

volume = "8",

pages = "3432--3442",

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TY - JOUR

T1 - Role of phytochemicals in the modulation of miRNA expression in cancer

AU - Debnath, Trishna

AU - Deb Nath, Narayan Chandra

AU - Kim, Eun Kyung

AU - Lee, Kwang Geun

PY - 2017/10

Y1 - 2017/10

N2 - MicroRNAs (miRNAs) are single-stranded non-coding endogenous RNAs linked with normal developmental and physiological processes. Recent studies have demonstrated that the dysregulation of miRNAs plays an important role in the beginning, progression, and metastasis of many cancers. Additionally, they are involved in the regulation of the epithelial-to-mesenchymal transition (EMT) in many cancer cells. Several studies have suggested that phytochemicals play an important role in the modulation of miRNA expression, which is related to changes in oncogenes, tumour suppressors, and cancer-related protein expression. Hence, phytonutrients can suppress tumour development, prevent metastasis, reverse the EMT, and improve drug sensitivity via the modulation of miRNA expression. In this review, we discuss tumour-suppressing and oncogenic miRNAs and the mechanism of action for miRNAs as well as the role of phytochemicals in the modulation of miRNAs in various cancer cells.

AB - MicroRNAs (miRNAs) are single-stranded non-coding endogenous RNAs linked with normal developmental and physiological processes. Recent studies have demonstrated that the dysregulation of miRNAs plays an important role in the beginning, progression, and metastasis of many cancers. Additionally, they are involved in the regulation of the epithelial-to-mesenchymal transition (EMT) in many cancer cells. Several studies have suggested that phytochemicals play an important role in the modulation of miRNA expression, which is related to changes in oncogenes, tumour suppressors, and cancer-related protein expression. Hence, phytonutrients can suppress tumour development, prevent metastasis, reverse the EMT, and improve drug sensitivity via the modulation of miRNA expression. In this review, we discuss tumour-suppressing and oncogenic miRNAs and the mechanism of action for miRNAs as well as the role of phytochemicals in the modulation of miRNAs in various cancer cells.

UR - https://www.scopus.com/pages/publications/85031814542

U2 - 10.1039/c7fo00739f

DO - 10.1039/c7fo00739f

M3 - Review article

C2 - 28782785

AN - SCOPUS:85031814542

SN - 2042-6496

VL - 8

SP - 3432

EP - 3442

JO - Food and Function

JF - Food and Function

IS - 10

ER -

Role of phytochemicals in the modulation of miRNA expression in cancer

Abstract

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