Role of sirtuins in linking metabolic syndrome with depression

Juhyun Song, Jongpil Kim

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Depression is now widely regarded as a common disabling disorder that affects negatively the social functioning all over the world. Depression is associated with diverse phenomenon in brain such as neuroinflammation, synaptic dysfunction, and cognitive deficit. Recent studies reported that depression occurs by various metabolic changes, leading to metabolic syndrome. Sirtuins (SIRTs) are NAD+-dependent class III histone deacetylases, known to regulate diverse biological mechanism such as longevity, genomic stability, and inflammation. The modulation of sirtuin activity has been highlighted as a promising approach to reduce neurodegenerative processes. In this review, we summarize the recent discoveries regarding the potential relationship between SIRTs and depression caused by metabolic disorders (Mets). Ultimately, we suggest the possibility that SIRTs will be novel targets to alleviate neuropathogenesis induced by depression.

Original languageEnglish
Article number86
JournalFrontiers in Cellular Neuroscience
Volume10
Issue numberMAR2016
DOIs
StatePublished - 31 Mar 2016

Keywords

  • Depression
  • Inflammation
  • Metabolic syndrome
  • Neurotransmitter
  • Sirtuins (SIRTs)
  • Synaptic dysfunction

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