Role of sphingosylphosphorylcholine in tumor and tumor microenvironment

Mi Kyung Park, Chang Hoon Lee

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Sphingosylphosphorylcholine (SPC) is a unique type of lysosphingolipid found in some diseases, and has been studied in cardiovascular, neurological, and inflammatory phenomena. In particular, SPC's studies on cancer have been conducted mainly in terms of effects on cancer cells, and relatively little consideration has been given to aspects of tumor microenvironment. This review summarizes the effects of SPC on cancer and tumor microenvironment, and presents the results and prospects of modulators that regulate the various actions of SPC.

Original languageEnglish
Article number1696
JournalCancers
Volume11
Issue number11
DOIs
StatePublished - Nov 2019

Keywords

  • Inflammatory
  • Lysosphingolipids
  • Neurological
  • Sphingosylphosphorylcholine
  • Tumor microenvironment

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