Abstract
Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.
Original language | English |
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Article number | 2352 |
Pages (from-to) | 1-33 |
Number of pages | 33 |
Journal | Cells |
Volume | 9 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2020 |
Keywords
- Cholesterol synthesis
- Farnesyl-diphosphate farnesyltransferase 1
- Lipid rafts
- Prognostic marker
- Tumour progression