Roles of farnesyl-diphosphate farnesyltransferase 1 in tumour and tumour microenvironments

Nguyen Thi Ha, Chang Hoon Lee

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.

Original languageEnglish
Article number2352
Pages (from-to)1-33
Number of pages33
JournalCells
Volume9
Issue number11
DOIs
StatePublished - Nov 2020

Keywords

  • Cholesterol synthesis
  • Farnesyl-diphosphate farnesyltransferase 1
  • Lipid rafts
  • Prognostic marker
  • Tumour progression

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