Roles of farnesyl-diphosphate farnesyltransferase 1 in tumour and tumour microenvironments

Nguyen Thi Ha; Chang Hoon Lee

doi:10.3390/cells9112352

Roles of farnesyl-diphosphate farnesyltransferase 1 in tumour and tumour microenvironments

Nguyen Thi Ha
, Chang Hoon Lee

Department of Pharmacy

Dongguk University

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.

Original language	English
Article number	2352
Pages (from-to)	1-33
Number of pages	33
Journal	Cells
Volume	9
Issue number	11
DOIs	https://doi.org/10.3390/cells9112352
State	Published - Nov 2020

Keywords

Cholesterol synthesis
Farnesyl-diphosphate farnesyltransferase 1
Lipid rafts
Prognostic marker
Tumour progression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cells9112352

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title = "Roles of farnesyl-diphosphate farnesyltransferase 1 in tumour and tumour microenvironments",

abstract = "Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.",

keywords = "Cholesterol synthesis, Farnesyl-diphosphate farnesyltransferase 1, Lipid rafts, Prognostic marker, Tumour progression",

author = "Ha, \{Nguyen Thi\} and Lee, \{Chang Hoon\}",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = nov,

doi = "10.3390/cells9112352",

language = "English",

volume = "9",

pages = "1--33",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

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TY - JOUR

T1 - Roles of farnesyl-diphosphate farnesyltransferase 1 in tumour and tumour microenvironments

AU - Ha, Nguyen Thi

AU - Lee, Chang Hoon

PY - 2020/11

Y1 - 2020/11

N2 - Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.

AB - Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.

KW - Cholesterol synthesis

KW - Farnesyl-diphosphate farnesyltransferase 1

KW - Lipid rafts

KW - Prognostic marker

KW - Tumour progression

UR - https://www.scopus.com/pages/publications/85094837979

U2 - 10.3390/cells9112352

DO - 10.3390/cells9112352

M3 - Review article

C2 - 33113804

AN - SCOPUS:85094837979

SN - 2073-4409

VL - 9

SP - 1

EP - 33

JO - Cells

JF - Cells

IS - 11

M1 - 2352

ER -

Roles of farnesyl-diphosphate farnesyltransferase 1 in tumour and tumour microenvironments

Abstract

Keywords

UN SDGs

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