Salicinoyl Quinic Acids and Their Prostaglandin E2Production Inhibitory Activities from the Fruits ofCasearia grewiifolia

Piseth Nhoek; Sungjin Ahn; In Guk Park; Pisey Pel; Jungmoo Huh; Hyun Woo Kim; Jongmin Ahn; Piseth Khiev; Young Hee Choi; Kyeong Lee; Minsoo Noh; Young Won Chin

doi:10.1021/acs.jnatprod.1c00343

Salicinoyl Quinic Acids and Their Prostaglandin E₂Production Inhibitory Activities from the Fruits ofCasearia grewiifolia

Piseth Nhoek, Sungjin Ahn, In Guk Park, Pisey Pel, Jungmoo Huh, Hyun Woo Kim, Jongmin Ahn, Piseth Khiev, Young Hee Choi, Kyeong Lee, Minsoo Noh, Young Won Chin

Department of Pharmacy

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Phytochemical investigation on the dried fruits ofCasearia grewiifolialed to the identification of 10 new salicinoyl quinic acid derivatives ( 1 - 10 ), a new benzoyl quinic acid ( 11 ), and two known compounds ( 12 and 13 ). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E₂(PGE₂) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE₂production with IC₅₀values of 20.5 and 28.8 μM, respectively.

Original language	English
Pages (from-to)	2437-2446
Number of pages	10
Journal	Journal of Natural Products
Volume	84
Issue number	9
DOIs	https://doi.org/10.1021/acs.jnatprod.1c00343
State	Published - 24 Sep 2021

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title = "Salicinoyl Quinic Acids and Their Prostaglandin E2Production Inhibitory Activities from the Fruits ofCasearia grewiifolia",

abstract = "Phytochemical investigation on the dried fruits ofCasearia grewiifolialed to the identification of 10 new salicinoyl quinic acid derivatives ( 1 - 10 ), a new benzoyl quinic acid ( 11 ), and two known compounds ( 12 and 13 ). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E2(PGE2) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE2production with IC50values of 20.5 and 28.8 μM, respectively.",

author = "Piseth Nhoek and Sungjin Ahn and Park, {In Guk} and Pisey Pel and Jungmoo Huh and Kim, {Hyun Woo} and Jongmin Ahn and Piseth Khiev and Choi, {Young Hee} and Kyeong Lee and Minsoo Noh and Chin, {Young Won}",

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year = "2021",

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doi = "10.1021/acs.jnatprod.1c00343",

language = "English",

volume = "84",

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T1 - Salicinoyl Quinic Acids and Their Prostaglandin E2Production Inhibitory Activities from the Fruits ofCasearia grewiifolia

AU - Nhoek, Piseth

AU - Ahn, Sungjin

AU - Park, In Guk

AU - Pel, Pisey

AU - Huh, Jungmoo

AU - Kim, Hyun Woo

AU - Ahn, Jongmin

AU - Khiev, Piseth

AU - Choi, Young Hee

AU - Lee, Kyeong

AU - Noh, Minsoo

AU - Chin, Young Won

PY - 2021/9/24

Y1 - 2021/9/24

N2 - Phytochemical investigation on the dried fruits ofCasearia grewiifolialed to the identification of 10 new salicinoyl quinic acid derivatives ( 1 - 10 ), a new benzoyl quinic acid ( 11 ), and two known compounds ( 12 and 13 ). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E2(PGE2) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE2production with IC50values of 20.5 and 28.8 μM, respectively.

AB - Phytochemical investigation on the dried fruits ofCasearia grewiifolialed to the identification of 10 new salicinoyl quinic acid derivatives ( 1 - 10 ), a new benzoyl quinic acid ( 11 ), and two known compounds ( 12 and 13 ). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E2(PGE2) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE2production with IC50values of 20.5 and 28.8 μM, respectively.

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U2 - 10.1021/acs.jnatprod.1c00343

DO - 10.1021/acs.jnatprod.1c00343

M3 - Review article

C2 - 34463498

AN - SCOPUS:85114857693

SN - 0163-3864

VL - 84

SP - 2437

EP - 2446

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Salicinoyl Quinic Acids and Their Prostaglandin E₂Production Inhibitory Activities from the Fruits ofCasearia grewiifolia

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