Salicinoyl Quinic Acids and Their Prostaglandin E2Production Inhibitory Activities from the Fruits ofCasearia grewiifolia

Piseth Nhoek; Sungjin Ahn; In Guk Park; Pisey Pel; Jungmoo Huh; Hyun Woo Kim; Jongmin Ahn; Piseth Khiev; Young Hee Choi; Kyeong Lee; Minsoo Noh; Young Won Chin

doi:10.1021/acs.jnatprod.1c00343

Salicinoyl Quinic Acids and Their Prostaglandin E₂Production Inhibitory Activities from the Fruits ofCasearia grewiifolia

Piseth Nhoek
, Sungjin Ahn
, In Guk Park
, Pisey Pel
, Jungmoo Huh
, Hyun Woo Kim
, Jongmin Ahn
, Piseth Khiev
, Young Hee Choi
, Kyeong Lee
, Minsoo Noh
, Young Won Chin

Department of Pharmacy

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Phytochemical investigation on the dried fruits ofCasearia grewiifolialed to the identification of 10 new salicinoyl quinic acid derivatives ( 1 - 10 ), a new benzoyl quinic acid ( 11 ), and two known compounds ( 12 and 13 ). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E₂(PGE₂) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE₂production with IC₅₀values of 20.5 and 28.8 μM, respectively.

Original language	English
Pages (from-to)	2437-2446
Number of pages	10
Journal	Journal of Natural Products
Volume	84
Issue number	9
DOIs	https://doi.org/10.1021/acs.jnatprod.1c00343
State	Published - 24 Sep 2021

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10.1021/acs.jnatprod.1c00343

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title = "Salicinoyl Quinic Acids and Their Prostaglandin E2Production Inhibitory Activities from the Fruits ofCasearia grewiifolia",

abstract = "Phytochemical investigation on the dried fruits ofCasearia grewiifolialed to the identification of 10 new salicinoyl quinic acid derivatives ( 1 - 10 ), a new benzoyl quinic acid ( 11 ), and two known compounds ( 12 and 13 ). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E2(PGE2) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE2production with IC50values of 20.5 and 28.8 μM, respectively.",

author = "Piseth Nhoek and Sungjin Ahn and Park, \{In Guk\} and Pisey Pel and Jungmoo Huh and Kim, \{Hyun Woo\} and Jongmin Ahn and Piseth Khiev and Choi, \{Young Hee\} and Kyeong Lee and Minsoo Noh and Chin, \{Young Won\}",

note = "Publisher Copyright: {\textcopyright} 2021 American Chemical Society and American Society of Pharmacognosy",

year = "2021",

month = sep,

day = "24",

doi = "10.1021/acs.jnatprod.1c00343",

language = "English",

volume = "84",

pages = "2437--2446",

journal = "Journal of Natural Products",

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publisher = "American Chemical Society",

number = "9",

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TY - JOUR

T1 - Salicinoyl Quinic Acids and Their Prostaglandin E2Production Inhibitory Activities from the Fruits ofCasearia grewiifolia

AU - Nhoek, Piseth

AU - Ahn, Sungjin

AU - Park, In Guk

AU - Pel, Pisey

AU - Huh, Jungmoo

AU - Kim, Hyun Woo

AU - Ahn, Jongmin

AU - Khiev, Piseth

AU - Choi, Young Hee

AU - Lee, Kyeong

AU - Noh, Minsoo

AU - Chin, Young Won

PY - 2021/9/24

Y1 - 2021/9/24

N2 - Phytochemical investigation on the dried fruits ofCasearia grewiifolialed to the identification of 10 new salicinoyl quinic acid derivatives ( 1 - 10 ), a new benzoyl quinic acid ( 11 ), and two known compounds ( 12 and 13 ). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E2(PGE2) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE2production with IC50values of 20.5 and 28.8 μM, respectively.

AB - Phytochemical investigation on the dried fruits ofCasearia grewiifolialed to the identification of 10 new salicinoyl quinic acid derivatives ( 1 - 10 ), a new benzoyl quinic acid ( 11 ), and two known compounds ( 12 and 13 ). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E2(PGE2) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE2production with IC50values of 20.5 and 28.8 μM, respectively.

UR - https://www.scopus.com/pages/publications/85114857693

U2 - 10.1021/acs.jnatprod.1c00343

DO - 10.1021/acs.jnatprod.1c00343

M3 - Review article

C2 - 34463498

AN - SCOPUS:85114857693

SN - 0163-3864

VL - 84

SP - 2437

EP - 2446

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Salicinoyl Quinic Acids and Their Prostaglandin E₂Production Inhibitory Activities from the Fruits ofCasearia grewiifolia

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