Salusin-β mediate neuroprotective effects for Parkinson's disease

Yujung Chang, Junsang Yoo, Hongwon Kim, Hi Joon Park, Songhee Jeon, Jongpil Kim

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Neuropeptides, small peptides found in many mammalian brain, play key roles in communicating with each other to modulate neuronal activity. Here, we reported that endogenous neuropeptide salusin-β has neuroprotective effects on the midbrain dopamine neurons and can be used as an effective therapeutic treatment for Parkinson's disease (PD). We found that the MrgprA1 receptor mediates the neuroprotective effects of salusin-β on the midbrain dopamine neurons. Importantly, intranasal administration of salusin-β in a PD mouse model show the neuroprotection of dopaminergic neurons and increased the survival of midbrain dopamine neurons. Furthermore, inhibition of the salusin-β receptor, MrgprA1, abolished the neuroprotective effects induced by salusin-β. Taken together, these results demonstrate the novel role of salusin-β in the central nervous system and salusin-β can be used as a novel therapeutic to effectively treat PD.

Original languageEnglish
Pages (from-to)1428-1433
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume503
Issue number3
DOIs
StatePublished - 10 Sep 2018

Keywords

  • Neuropeptide
  • Neuroprotective effect
  • Parkinson's disease
  • Salusin-β

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