TY - JOUR
T1 - Scaffolds for bone-tissue engineering
AU - Lee, Seunghun S.
AU - Du, Xiaoyu
AU - Kim, Inseon
AU - Ferguson, Stephen J.
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/9/7
Y1 - 2022/9/7
N2 - Due to a prolonged life expectancy, the number of orthopedic-related fractures and pathologies is increasing, leading to a tremendous demand for efficient orthopedic treatment. Consequently, bone-tissue engineering (BTE) has been developed to provide the innovative solution of using scaffolds to regenerate bone tissue. To fabricate an ideal scaffold, it is important to consider the characteristics of biomaterials and the biomechanical properties of the scaffold for structural restoration and tissue regeneration. Herein, an overview is provided on the properties of an ideal scaffold such as stiffness, pore size, surface topology, and load-bearing capacity. In addition, we categorized biomaterials for BTE scaffolds into four groups, ceramic, metal, natural polymer, and synthetic polymer, and elaborate on relevant mechanical and biological aspects of representative biomaterials from each group. Furthermore, we reviewed and highlighted recent advances in scaffolds that have been developed in the past 10 years in BTE.
AB - Due to a prolonged life expectancy, the number of orthopedic-related fractures and pathologies is increasing, leading to a tremendous demand for efficient orthopedic treatment. Consequently, bone-tissue engineering (BTE) has been developed to provide the innovative solution of using scaffolds to regenerate bone tissue. To fabricate an ideal scaffold, it is important to consider the characteristics of biomaterials and the biomechanical properties of the scaffold for structural restoration and tissue regeneration. Herein, an overview is provided on the properties of an ideal scaffold such as stiffness, pore size, surface topology, and load-bearing capacity. In addition, we categorized biomaterials for BTE scaffolds into four groups, ceramic, metal, natural polymer, and synthetic polymer, and elaborate on relevant mechanical and biological aspects of representative biomaterials from each group. Furthermore, we reviewed and highlighted recent advances in scaffolds that have been developed in the past 10 years in BTE.
KW - biomaterials
KW - bone regeneration
KW - bone tissue engineering
KW - cellular differentiation
KW - mechanical properties
KW - osteogenesis
KW - scaffold
UR - http://www.scopus.com/inward/record.url?scp=85137651691&partnerID=8YFLogxK
U2 - 10.1016/j.matt.2022.06.003
DO - 10.1016/j.matt.2022.06.003
M3 - Review article
AN - SCOPUS:85137651691
SN - 2590-2393
VL - 5
SP - 2722
EP - 2759
JO - Matter
JF - Matter
IS - 9
ER -