TY - JOUR
T1 - Self-assembling biomolecules for biosensor applications
AU - Kim, Ji eun
AU - Kang, Jeon Hyeong
AU - Kwon, Woo Hyun
AU - Lee, Inseo
AU - Park, Sang Jun
AU - Kim, Chun Ho
AU - Jeong, Woo jin
AU - Choi, Jun Shik
AU - Kim, Kyobum
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Molecular self-assembly has received considerable attention in biomedical fields as a simple and effective method for developing biomolecular nanostructures. Self-assembled nanostructures can exhibit high binding affinity and selectivity by displaying multiple ligands/receptors on their surface. In addition, the use of supramolecular structure change upon binding is an intriguing approach to generate binding signal. Therefore, many self-assembled nanostructure-based biosensors have been developed over the past decades, using various biomolecules (e.g., peptides, DNA, RNA, lipids) and their combinations with non-biological substances. In this review, we provide an overview of recent developments in the design and fabrication of self-assembling biomolecules for biosensing. Furthermore, we discuss representative electrochemical biosensing platforms which convert the biochemical reactions of those biomolecules into electrical signals (e.g., voltage, ampere, potential difference, impedance) to contribute to detect targets. This paper also highlights the successful outcomes of self-assembling biomolecules in biosensor applications and discusses the challenges that this promising technology needs to overcome for more widespread use. Graphical Abstract: [Figure not available: see fulltext.].
AB - Molecular self-assembly has received considerable attention in biomedical fields as a simple and effective method for developing biomolecular nanostructures. Self-assembled nanostructures can exhibit high binding affinity and selectivity by displaying multiple ligands/receptors on their surface. In addition, the use of supramolecular structure change upon binding is an intriguing approach to generate binding signal. Therefore, many self-assembled nanostructure-based biosensors have been developed over the past decades, using various biomolecules (e.g., peptides, DNA, RNA, lipids) and their combinations with non-biological substances. In this review, we provide an overview of recent developments in the design and fabrication of self-assembling biomolecules for biosensing. Furthermore, we discuss representative electrochemical biosensing platforms which convert the biochemical reactions of those biomolecules into electrical signals (e.g., voltage, ampere, potential difference, impedance) to contribute to detect targets. This paper also highlights the successful outcomes of self-assembling biomolecules in biosensor applications and discusses the challenges that this promising technology needs to overcome for more widespread use. Graphical Abstract: [Figure not available: see fulltext.].
KW - Electrochemical biosensor
KW - Molecular self-assembly
KW - Supramolecular biosensor
UR - http://www.scopus.com/inward/record.url?scp=85178439910&partnerID=8YFLogxK
U2 - 10.1186/s40824-023-00466-8
DO - 10.1186/s40824-023-00466-8
M3 - Review article
AN - SCOPUS:85178439910
SN - 2055-7124
VL - 27
JO - Biomaterials Research
JF - Biomaterials Research
IS - 1
M1 - 127
ER -