Self-assembling biomolecules for biosensor applications

Ji eun Kim, Jeon Hyeong Kang, Woo Hyun Kwon, Inseo Lee, Sang Jun Park, Chun Ho Kim, Woo jin Jeong, Jun Shik Choi, Kyobum Kim

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Molecular self-assembly has received considerable attention in biomedical fields as a simple and effective method for developing biomolecular nanostructures. Self-assembled nanostructures can exhibit high binding affinity and selectivity by displaying multiple ligands/receptors on their surface. In addition, the use of supramolecular structure change upon binding is an intriguing approach to generate binding signal. Therefore, many self-assembled nanostructure-based biosensors have been developed over the past decades, using various biomolecules (e.g., peptides, DNA, RNA, lipids) and their combinations with non-biological substances. In this review, we provide an overview of recent developments in the design and fabrication of self-assembling biomolecules for biosensing. Furthermore, we discuss representative electrochemical biosensing platforms which convert the biochemical reactions of those biomolecules into electrical signals (e.g., voltage, ampere, potential difference, impedance) to contribute to detect targets. This paper also highlights the successful outcomes of self-assembling biomolecules in biosensor applications and discusses the challenges that this promising technology needs to overcome for more widespread use. Graphical Abstract: [Figure not available: see fulltext.].

Original languageEnglish
Article number127
JournalBiomaterials Research
Volume27
Issue number1
DOIs
StatePublished - Dec 2023

Keywords

  • Electrochemical biosensor
  • Molecular self-assembly
  • Supramolecular biosensor

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