Self-detachable UV-curable polymers for open-access microfluidic platforms

Dongha Tahk, Seokyoung Bang, Sujin Hyung, Jungeun Lim, James Yu, Jinhyun Kim, Noo Li Jeon, Hong Nam Kim

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This study presents an ultraviolet (UV)-curable polymer which is applicable to open-access microfluidic platforms. The UV-curable polymer was prepared by mixing trimethylolpropane triacrylate (TMPTA), 1,6-hexanediol diacrylate (HDDA), polyethylene glycol-diacrylate (PEG-DA), and Irgacure 184. The polymer resin is optically transparent before and after UV-assisted curing and showed good biocompatibility when culturing multiple types of cells on the nanopatterned polymer substrate. The polymer has good adhesion with poly(dimethylsiloxane) (PDMS) even under large deformation and showed a low swelling ratio when exposed to water, suggesting a possibility to be used as a substrate for an organ on a chip. Furthermore, because the polymers have controllable hydrolysis ability depending on the composition, long-term 3D cell culture and subsequent biological analysis with harvested cells are possible. The self-detachable synthesized UV-curable polymer may help the advancement of biomedical studies using in vitro cell culture.

Original languageEnglish
Pages (from-to)4215-4224
Number of pages10
JournalLab on a Chip
Volume20
Issue number22
DOIs
StatePublished - 21 Nov 2020

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