TY - JOUR
T1 - Self-healable and dual-functional guar gum-grafted-polyacrylamidoglycolic acid-based hydrogels with nano-silver for wound dressings
AU - Palem, Ramasubba Reddy
AU - Madhusudana Rao, Kummara
AU - Kang, Tae June
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Dual-functional carbohydrate polymer-based silver nanocomposite (AgNC) hydrogels with self-healing, injectable, and bacterial inactivation properties have attracted particular attention in the wound dressing field. In this study, a rapid formation of AgNC hydrogels were prepared via in situ addition of guar gum-grafted-polyacrylamidoglycolic acid (GG-g-PAGA) polymer and silver nitrate (AgNO3) and sodium borohydride (NaBH4). The GG-g-PAGA polymer and its AgNC hydrogels were analyzed by FTIR, 1H and 13C NMR, UV–vis spectra, FE-SEM, EDX, and FE-TEM. The GG-g-PAGA@AgNC hydrogels exhibited self-healing ability, injectability, stretchability, flowability, high swelling, porosity, upright mechanical behavior, and biodegradability. Moreover, their bacterial inactivation and cytotoxicity were tested against wound pathogens and skin fibroblast cells, respectively. Therefore, incorporating GG-g-PAGA@AgNC hydrogels could be a versatile strategy to speed up wound healing processes, but a clinical trial is still required for its medical applications.
AB - Dual-functional carbohydrate polymer-based silver nanocomposite (AgNC) hydrogels with self-healing, injectable, and bacterial inactivation properties have attracted particular attention in the wound dressing field. In this study, a rapid formation of AgNC hydrogels were prepared via in situ addition of guar gum-grafted-polyacrylamidoglycolic acid (GG-g-PAGA) polymer and silver nitrate (AgNO3) and sodium borohydride (NaBH4). The GG-g-PAGA polymer and its AgNC hydrogels were analyzed by FTIR, 1H and 13C NMR, UV–vis spectra, FE-SEM, EDX, and FE-TEM. The GG-g-PAGA@AgNC hydrogels exhibited self-healing ability, injectability, stretchability, flowability, high swelling, porosity, upright mechanical behavior, and biodegradability. Moreover, their bacterial inactivation and cytotoxicity were tested against wound pathogens and skin fibroblast cells, respectively. Therefore, incorporating GG-g-PAGA@AgNC hydrogels could be a versatile strategy to speed up wound healing processes, but a clinical trial is still required for its medical applications.
KW - Acrylamidoglycolic acid
KW - Cytotoxicity
KW - Guar gum grafting
KW - Self-healing
KW - Silver nanocomposite hydrogel
KW - Wound dressing
UR - http://www.scopus.com/inward/record.url?scp=85068994834&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2019.115074
DO - 10.1016/j.carbpol.2019.115074
M3 - Article
C2 - 31427000
AN - SCOPUS:85068994834
SN - 0144-8617
VL - 223
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 115074
ER -