TY - JOUR
T1 - Sericin based nanoformulations
T2 - a comprehensive review on molecular mechanisms of interaction with organisms to biological applications
AU - Das, Gitishree
AU - Shin, Han Seung
AU - Campos, Estefânia V.Ramos
AU - Fraceto, Leonardo Fernandes
AU - del Pilar Rodriguez-Torres, Maria
AU - Mariano, Kelli Cristina Freitas
AU - de Araujo, Daniele Ribeiro
AU - Fernández-Luqueño, Fabián
AU - Grillo, Renato
AU - Patra, Jayanta Kumar
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Background: The advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials. Main body: Sericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells. Conclusion: In this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.[Figure not available: see fulltext.]
AB - Background: The advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials. Main body: Sericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells. Conclusion: In this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.[Figure not available: see fulltext.]
KW - Biomaterials
KW - Biomedical
KW - Drug delivery
KW - Nanoformulation
KW - Sericin
KW - Silk protein
UR - http://www.scopus.com/inward/record.url?scp=85099793128&partnerID=8YFLogxK
U2 - 10.1186/s12951-021-00774-y
DO - 10.1186/s12951-021-00774-y
M3 - Review article
C2 - 33482828
AN - SCOPUS:85099793128
SN - 1477-3155
VL - 19
JO - Journal of Nanobiotechnology
JF - Journal of Nanobiotechnology
IS - 1
M1 - 30
ER -