Simulation model of trabecular bone remodeling considering effects of osteocyte apoptosis and targeted remodeling

Jiyean Kwon, Hisashi Naito, Takeshi Matsumoto, Masao Tanaka

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Bone structure is renewed or restructured in part by a load-dependent remodeling. In this study, a mathematical model of bone surface remodeling over a wide range of strain was established. We assumed that in a low strain range, bone resorption occurs at an accelerated rate with strain decrease owing to low strain-induced osteocyte apoptosis, and that in a high strain range, bone formation occurs at an accelerated rate with strain increase (targeted remodeling). In a physiological strain range, bone formation or resorption was assumed to occur stochastically according to the degree of local stress non-uniformity. The utility of the present model was examined through three-dimensional numerical simulation of femoral trabecular architecture.

Original languageEnglish
Pages (from-to)539-551
Number of pages13
JournalJournal of Biomechanical Science and Engineering
Volume5
Issue number5
DOIs
StatePublished - 2010

Keywords

  • Computational biomechanics
  • Osteocyte apoptosis
  • Remodeling turnover
  • Targeted remodeling

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