SIRT1 activation enhancing 8,3′-neolignans from the twigs of corylopsis coreana uyeki

Hyun Woo Kim; Jin Bum Jeon; Mi Zhang; Hyo Moon Cho; Byeol Ryu; Ba Wool Lee; William H. Gerwick; Won Keun Oh

doi:10.3390/plants10081684

SIRT1 activation enhancing 8,3^′-neolignans from the twigs of corylopsis coreana uyeki

Hyun Woo Kim, Jin Bum Jeon, Mi Zhang, Hyo Moon Cho, Byeol Ryu, Ba Wool Lee, William H. Gerwick, Won Keun Oh

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Three undescribed 8,3^′-neolignans, corynol (1), 3-methoxy-corynol (2) and 3^′-deoxy-corynol (3), together with two bergenin derivatives, three flavonoids, two hydrolysable tannins and six simple phenolic compounds, were isolated from the twigs of Corylopsis coreana Uyeki. The structures of the 8,3^′-neolignans were elucidated by analyzing their NMR, HRESIMS and ECD spectra. All the isolated compounds were evaluated for their SIRT1 stimulatory activity, and 3^′-deoxy-corynol (3) showed SIRT1 stimulation activity. Furthermore, a docking study of 3 was performed with three representative binding pockets of SIRT1.

Original language	English
Article number	1684
Journal	Plants
Volume	10
Issue number	8
DOIs	https://doi.org/10.3390/plants10081684
State	Published - Aug 2021

Keywords

Corylopsis coreana
Hamamelidacease
Neolignan
SIRT1

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title = "SIRT1 activation enhancing 8,3′-neolignans from the twigs of corylopsis coreana uyeki",

abstract = "Three undescribed 8,3′-neolignans, corynol (1), 3-methoxy-corynol (2) and 3′-deoxy-corynol (3), together with two bergenin derivatives, three flavonoids, two hydrolysable tannins and six simple phenolic compounds, were isolated from the twigs of Corylopsis coreana Uyeki. The structures of the 8,3′-neolignans were elucidated by analyzing their NMR, HRESIMS and ECD spectra. All the isolated compounds were evaluated for their SIRT1 stimulatory activity, and 3′-deoxy-corynol (3) showed SIRT1 stimulation activity. Furthermore, a docking study of 3 was performed with three representative binding pockets of SIRT1.",

keywords = "Corylopsis coreana, Hamamelidacease, Neolignan, SIRT1",

author = "Kim, {Hyun Woo} and Jeon, {Jin Bum} and Mi Zhang and Cho, {Hyo Moon} and Byeol Ryu and Lee, {Ba Wool} and Gerwick, {William H.} and Oh, {Won Keun}",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = aug,

doi = "10.3390/plants10081684",

language = "English",

volume = "10",

journal = "Plants",

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T1 - SIRT1 activation enhancing 8,3′-neolignans from the twigs of corylopsis coreana uyeki

AU - Kim, Hyun Woo

AU - Jeon, Jin Bum

AU - Zhang, Mi

AU - Cho, Hyo Moon

AU - Ryu, Byeol

AU - Lee, Ba Wool

AU - Gerwick, William H.

AU - Oh, Won Keun

PY - 2021/8

Y1 - 2021/8

N2 - Three undescribed 8,3′-neolignans, corynol (1), 3-methoxy-corynol (2) and 3′-deoxy-corynol (3), together with two bergenin derivatives, three flavonoids, two hydrolysable tannins and six simple phenolic compounds, were isolated from the twigs of Corylopsis coreana Uyeki. The structures of the 8,3′-neolignans were elucidated by analyzing their NMR, HRESIMS and ECD spectra. All the isolated compounds were evaluated for their SIRT1 stimulatory activity, and 3′-deoxy-corynol (3) showed SIRT1 stimulation activity. Furthermore, a docking study of 3 was performed with three representative binding pockets of SIRT1.

AB - Three undescribed 8,3′-neolignans, corynol (1), 3-methoxy-corynol (2) and 3′-deoxy-corynol (3), together with two bergenin derivatives, three flavonoids, two hydrolysable tannins and six simple phenolic compounds, were isolated from the twigs of Corylopsis coreana Uyeki. The structures of the 8,3′-neolignans were elucidated by analyzing their NMR, HRESIMS and ECD spectra. All the isolated compounds were evaluated for their SIRT1 stimulatory activity, and 3′-deoxy-corynol (3) showed SIRT1 stimulation activity. Furthermore, a docking study of 3 was performed with three representative binding pockets of SIRT1.

KW - Corylopsis coreana

KW - Hamamelidacease

KW - Neolignan

KW - SIRT1

UR - http://www.scopus.com/inward/record.url?scp=85112493853&partnerID=8YFLogxK

U2 - 10.3390/plants10081684

DO - 10.3390/plants10081684

M3 - Article

AN - SCOPUS:85112493853

SN - 2223-7747

VL - 10

JO - Plants

JF - Plants

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ER -

SIRT1 activation enhancing 8,3^′-neolignans from the twigs of corylopsis coreana uyeki

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Keywords

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