Spiroketones and a biphenyl analog from stems and leaves of Larrea nitida and their inhibitory activity against IL-6 production

Jongmin Ahn, Yihua Pei, Hee Sung Chae, Seong Hwan Kim, Young Mi Kim, Young Hee Choi, Joongku Lee, Minsun Chang, Yun Seon Song, Roberto Rodriguez, Dong Chan Oh, Jinwoong Kim, Sangho Choi, Sang Hoon Joo, Young Won Chin

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Bioactivity-guided fractionation for the stems of leaves of Larrea nitida Cav., using interleukin-6 (IL-6) inhibitory assay in human mast cells (HMC-1), led to the isolation of three new compounds with an unprecedented skeleton in nature (1-3) and three known compounds (4-6). Their structures were elucidated through extensive spectroscopic analysis. The three new compounds were elucidated as two new spiroketones, nitidaones A (1), and B (2) and one new biphenyl analog, nitidaol (3). The known compounds were identified as nordihydroguaiaretic acid (4), 7,3',4'-tri-O-methylquercetin (5) and ayanin (6). All the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells. Of them, compounds 1, 3-6 showed potent anti-inflammatory activity, with IC50 values of 12.8, 17.5, 14.9, 22.9, and 17.8 μM, respectively.

Original languageEnglish
Article number302
JournalMolecules
Volume23
Issue number2
DOIs
StatePublished - 2018

Keywords

  • Biphenyl analog
  • HMC-1
  • IL-6
  • Larrea nitida
  • Spiroketones

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