Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples

Huy X. Luong, Young Woo Kim

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Polyproline II helix (PPII) is one of the secondary structures in proteins that play an important role in various biological processes. In this study, we have developed a new macrocyclization strategy that efficiently reinforces a model tetrapeptide into a PPII structure. We also elucidated some relationships between structural features and PPII stability in this model. This new macrocyclic stapling strategy can serve as a useful chemical tool to manipulate the PPII structure for various applications.

Original languageEnglish
Pages (from-to)7986-7990
Number of pages5
JournalOrganic Letters
Volume22
Issue number20
DOIs
StatePublished - 16 Oct 2020

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