Abstract
Polyproline II helix (PPII) is one of the secondary structures in proteins that play an important role in various biological processes. In this study, we have developed a new macrocyclization strategy that efficiently reinforces a model tetrapeptide into a PPII structure. We also elucidated some relationships between structural features and PPII stability in this model. This new macrocyclic stapling strategy can serve as a useful chemical tool to manipulate the PPII structure for various applications.
Original language | English |
---|---|
Pages (from-to) | 7986-7990 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 22 |
Issue number | 20 |
DOIs | |
State | Published - 16 Oct 2020 |