Abstract
Cells interact with various nanoscaled topographical and biochemical cues in their cellular macromolecular environment. Nanotopography recreates or mimic the cellular macromolecular environment in vitro. The influence of material surface topography on the behavior of adherent cells has been studied. Current techniques enable various kinds of nanopatterned surface to be generated and applied to cells. The purpose of this review is to provide an overview of nanotopography and its surface patterns, and introduce nanoto-pography effects on cell behavior including cell attachment, proliferation, and cell differentiation with particular emphasis on musculoskeletal regeneration.
Original language | English |
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Pages (from-to) | 1238-1245 |
Number of pages | 8 |
Journal | Journal of Biomedical Materials Research - Part A |
Volume | 103 |
Issue number | 3 |
DOIs | |
State | Published - 1 Mar 2015 |
Keywords
- Musculoskeletal regeneration
- Nanotopography
- Stem cells