Stereoselective synthesis of 3-hydroxymethyl-D-cyclopentenone, the versatile intermediate for the synthesis of carbocyclic nucleosides

  • Won Jun Choi
  • , Hyung Ryong Moon
  • , Hea Ok Kim
  • , Young Mi Ko
  • , Hye Jin Kim
  • , Jeong A. Lee
  • , Kang Man Lee
  • , Mi Kyung Yun
  • , Dae Hong Shin
  • , Moon Woo Chun
  • , Yhun Y. Sheen
  • , Kilhyoun Kim
  • , Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The preparative and stereoselective synthesis (45-50% overall yields, >50 g scale) of the key carbasugars 7a-d was achieved from D-ribose via stereoselective Grignard reaction and oxidative rearrangement as key reactions.

Original languageEnglish
Pages (from-to)611-613
Number of pages3
JournalNucleosides, Nucleotides and Nucleic Acids
Volume24
Issue number5-7
DOIs
StatePublished - 2005

Keywords

  • 3-Hydroxymethyl-D-cyclopentenone
  • Carbocyclic Nucleosides

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