Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme

Hyuk Woo Lee, Soo Kyung Nam, Won Jun Choi, Hea Ok Kim, Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and selective displacement of a cyclic sulfate moiety as key steps.

Original languageEnglish
Pages (from-to)3557-3561
Number of pages5
JournalJournal of Organic Chemistry
Volume76
Issue number9
DOIs
StatePublished - 6 May 2011

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