Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme

Hyuk Woo Lee; Soo Kyung Nam; Won Jun Choi; Hea Ok Kim; Lak Shin Jeong

doi:10.1021/jo2001897

Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme

Hyuk Woo Lee
, Soo Kyung Nam
, Won Jun Choi
, Hea Ok Kim
, Lak Shin Jeong

Department of Pharmacy

Ewha Womans University

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and selective displacement of a cyclic sulfate moiety as key steps.

Original language	English
Pages (from-to)	3557-3561
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	76
Issue number	9
DOIs	https://doi.org/10.1021/jo2001897
State	Published - 6 May 2011

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title = "Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme",

abstract = "MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and selective displacement of a cyclic sulfate moiety as key steps.",

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year = "2011",

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doi = "10.1021/jo2001897",

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journal = "Journal of Organic Chemistry",

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AU - Lee, Hyuk Woo

AU - Nam, Soo Kyung

AU - Choi, Won Jun

AU - Kim, Hea Ok

AU - Jeong, Lak Shin

PY - 2011/5/6

Y1 - 2011/5/6

N2 - MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and selective displacement of a cyclic sulfate moiety as key steps.

AB - MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and selective displacement of a cyclic sulfate moiety as key steps.

UR - https://www.scopus.com/pages/publications/79955565555

U2 - 10.1021/jo2001897

DO - 10.1021/jo2001897

M3 - Article

C2 - 21417215

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SN - 0022-3263

VL - 76

SP - 3557

EP - 3561

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 9

ER -

Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme

Abstract

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