Structure-activity relationships of apio nucleosides as potential antiviral agents

Lak Shin Jeong, Hyung Ryong Moon, Jun Hee Hong, Su Jeong Yoo, Won Jun Choi, Hea Ok Kim, Hee Sung Ahn, Hye Woo Baek, Moon Woo Chun, Hee Doo Kim, Jeongmin Kim, Jong Ryoo Choi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.

Original languageEnglish
Pages (from-to)657-660
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume20
Issue number4-7
DOIs
StatePublished - 2001

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