Abstract
Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.
Original language | English |
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Pages (from-to) | 657-660 |
Number of pages | 4 |
Journal | Nucleosides, Nucleotides and Nucleic Acids |
Volume | 20 |
Issue number | 4-7 |
DOIs | |
State | Published - 2001 |