Structure-activity relationships of apio nucleosides as potential antiviral agents

Lak Shin Jeong; Hyung Ryong Moon; Jun Hee Hong; Su Jeong Yoo; Won Jun Choi; Hea Ok Kim; Hee Sung Ahn; Hye Woo Baek; Moon Woo Chun; Hee Doo Kim; Jeongmin Kim; Jong Ryoo Choi

doi:10.1081/NCN-100002344

Structure-activity relationships of apio nucleosides as potential antiviral agents

Lak Shin Jeong
, Hyung Ryong Moon
, Jun Hee Hong
, Su Jeong Yoo
, Won Jun Choi
, Hea Ok Kim
, Hee Sung Ahn
, Hye Woo Baek
, Moon Woo Chun
, Hee Doo Kim
, Jeongmin Kim
, Jong Ryoo Choi

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.

Original language	English
Pages (from-to)	657-660
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	20
Issue number	4-7
DOIs	https://doi.org/10.1081/NCN-100002344
State	Published - 2001

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10.1081/NCN-100002344

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title = "Structure-activity relationships of apio nucleosides as potential antiviral agents",

abstract = "Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.",

author = "Jeong, \{Lak Shin\} and Moon, \{Hyung Ryong\} and Hong, \{Jun Hee\} and Yoo, \{Su Jeong\} and Choi, \{Won Jun\} and Kim, \{Hea Ok\} and Ahn, \{Hee Sung\} and Baek, \{Hye Woo\} and Chun, \{Moon Woo\} and Kim, \{Hee Doo\} and Jeongmin Kim and Choi, \{Jong Ryoo\}",

year = "2001",

doi = "10.1081/NCN-100002344",

language = "English",

volume = "20",

pages = "657--660",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

issn = "1525-7770",

publisher = "Taylor and Francis Ltd.",

number = "4-7",

}

TY - JOUR

T1 - Structure-activity relationships of apio nucleosides as potential antiviral agents

AU - Jeong, Lak Shin

AU - Moon, Hyung Ryong

AU - Hong, Jun Hee

AU - Yoo, Su Jeong

AU - Choi, Won Jun

AU - Kim, Hea Ok

AU - Ahn, Hee Sung

AU - Baek, Hye Woo

AU - Chun, Moon Woo

AU - Kim, Hee Doo

AU - Kim, Jeongmin

AU - Choi, Jong Ryoo

PY - 2001

Y1 - 2001

N2 - Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.

AB - Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.

UR - https://www.scopus.com/pages/publications/0034839590

U2 - 10.1081/NCN-100002344

DO - 10.1081/NCN-100002344

M3 - Article

C2 - 11563085

AN - SCOPUS:0034839590

SN - 1525-7770

VL - 20

SP - 657

EP - 660

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 4-7

ER -

Structure-activity relationships of apio nucleosides as potential antiviral agents

Abstract

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