Structure elucidation of a new triterpene from Inonotus obliquus

Sangmin Park; Hyeji Shin; Dawon Park; Hyunwoo Kim; Youngjoo Byun; Ki Yong Lee

doi:10.1002/mrc.5102

Structure elucidation of a new triterpene from Inonotus obliquus

Sangmin Park, Hyeji Shin, Dawon Park, Hyunwoo Kim, Youngjoo Byun, Ki Yong Lee

Department of Pharmacy

Korea University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Ethyl acetate (EtOAc) fraction of the Inonotus obliquus (Hymenochaetaceae) significantly inhibited nitric oxide production in lipopolysaccharide (LPS)–induced murine BV2 microglial cells. A new triterpene, characterized as inonotusol H (1), was isolated from the EtOAc fraction using the bioactivity-guided fractionation together with four known triterpenes, inotodiol (2), trametenolic acid (3), inonotsutriols A (4), and inonotusol A (5). Among them, Compounds 2–4 significantly reduced LPS-induced nitric oxide production to 4.5 ± 0.8%, 47.4 ± 4.4%, and 2.8 ± 1.7%, respectively, at a concentration of 30 μM.

Original language	English
Pages (from-to)	489-494
Number of pages	6
Journal	Magnetic Resonance in Chemistry
Volume	59
Issue number	4
DOIs	https://doi.org/10.1002/mrc.5102
State	Published - Apr 2021

Keywords

anti-inflammatory
Inonotus obliquus
lanostane-type triterpene

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10.1002/mrc.5102

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title = "Structure elucidation of a new triterpene from Inonotus obliquus",

abstract = "Ethyl acetate (EtOAc) fraction of the Inonotus obliquus (Hymenochaetaceae) significantly inhibited nitric oxide production in lipopolysaccharide (LPS)–induced murine BV2 microglial cells. A new triterpene, characterized as inonotusol H (1), was isolated from the EtOAc fraction using the bioactivity-guided fractionation together with four known triterpenes, inotodiol (2), trametenolic acid (3), inonotsutriols A (4), and inonotusol A (5). Among them, Compounds 2–4 significantly reduced LPS-induced nitric oxide production to 4.5 ± 0.8%, 47.4 ± 4.4%, and 2.8 ± 1.7%, respectively, at a concentration of 30 μM.",

keywords = "anti-inflammatory, Inonotus obliquus, lanostane-type triterpene",

author = "Sangmin Park and Hyeji Shin and Dawon Park and Hyunwoo Kim and Youngjoo Byun and Lee, {Ki Yong}",

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T1 - Structure elucidation of a new triterpene from Inonotus obliquus

AU - Park, Sangmin

AU - Shin, Hyeji

AU - Park, Dawon

AU - Kim, Hyunwoo

AU - Byun, Youngjoo

AU - Lee, Ki Yong

PY - 2021/4

Y1 - 2021/4

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AB - Ethyl acetate (EtOAc) fraction of the Inonotus obliquus (Hymenochaetaceae) significantly inhibited nitric oxide production in lipopolysaccharide (LPS)–induced murine BV2 microglial cells. A new triterpene, characterized as inonotusol H (1), was isolated from the EtOAc fraction using the bioactivity-guided fractionation together with four known triterpenes, inotodiol (2), trametenolic acid (3), inonotsutriols A (4), and inonotusol A (5). Among them, Compounds 2–4 significantly reduced LPS-induced nitric oxide production to 4.5 ± 0.8%, 47.4 ± 4.4%, and 2.8 ± 1.7%, respectively, at a concentration of 30 μM.

KW - anti-inflammatory

KW - Inonotus obliquus

KW - lanostane-type triterpene

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U2 - 10.1002/mrc.5102

DO - 10.1002/mrc.5102

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SP - 489

EP - 494

JO - Magnetic Resonance in Chemistry

JF - Magnetic Resonance in Chemistry

IS - 4

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Structure elucidation of a new triterpene from Inonotus obliquus

Abstract

Keywords

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