TY - GEN
T1 - Sustained release of bone morphogenetic protein-2 in interpenetrating composite hydrogels for promoting skull bone regeneration
AU - Kim, Sungjun
AU - Kim, Junhyung
AU - Kang, Byung Jae
AU - Kim, Kyobum
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Large craniofacial defect by trauma, congenital disease, or cancer resection raises serious difficulties for reconstructive surgeons. To date, bone tissue engineering applications have been developed to substitute these conventional medical approaches. A variety of biopolymer-based scaffold materials, especially hydrogels, have been used as effective growth factor (GF) carriers. Furthermore, bone morphogenetic protein-2 (BMP-2) is one of the most well known GF for promoting bone regeneration. Since, BMPs have a short half-life from about several minutes to hours in the body, a large amount of BMP is usually required to obtain a desired bone formation. However, direct administration of high dose of BMP-2 could cause various clinical side effects. Therefore, in this study, to achieve a sustained release of bioactive BMP-2 for skull bone regeneration, composite interpenetrating (IPN) hydrogel with polycation-based coacervate (Coa) and gelatin microparticle (GMP) as BMP-2 carriers were developed.
AB - Large craniofacial defect by trauma, congenital disease, or cancer resection raises serious difficulties for reconstructive surgeons. To date, bone tissue engineering applications have been developed to substitute these conventional medical approaches. A variety of biopolymer-based scaffold materials, especially hydrogels, have been used as effective growth factor (GF) carriers. Furthermore, bone morphogenetic protein-2 (BMP-2) is one of the most well known GF for promoting bone regeneration. Since, BMPs have a short half-life from about several minutes to hours in the body, a large amount of BMP is usually required to obtain a desired bone formation. However, direct administration of high dose of BMP-2 could cause various clinical side effects. Therefore, in this study, to achieve a sustained release of bioactive BMP-2 for skull bone regeneration, composite interpenetrating (IPN) hydrogel with polycation-based coacervate (Coa) and gelatin microparticle (GMP) as BMP-2 carriers were developed.
UR - http://www.scopus.com/inward/record.url?scp=85065442384&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85065442384
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 72
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -
