Synergic effect of trimebutine combined with mosapride on gastrointestinal dysfunction and visceral pain induced in stress models

Young Joon Park, Yong Sul Park, Zoo Chul Chung, Yun Sung Nam, Yoon Hee Chung, Kwan Hyung Cho, Sung Up Choi, Uy Dong Sohn, Eon Sub Park, Hyun Dong Je, Choongho Lee, Moo Yeol Lee, Ji Hoon Jeong

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was undertaken to determine whether combined treatment with prokinetic trimebutine and mosapride has a synergic effect on gastrointestinal motility and visceral pain associated with gastrointestinal dysfunction. To develop effective gastroprokinetic agents with greater potencies than trimebutine or mosapride for the treatment of gastrointestinal tract disease, a mixture of trimebutine and mosapride was designed and prepared. In the present study, treatment with trimebutine alone showed a dose-dependent effect on propelling movements of normal small and large intestine in mice, whereas mosapride effected only small intestine motility. Co-administration of trimebutine with mosapride, a well-established prokinetic drug, produced a synergistic infl uence on normal small intestine motility, but demonstrated an unclear effect on large intestine motility, with a slight tendency to reduce the propelling time. In a stress model, the small and large intestine motilities were signifi cantly decreased. The reduction of intestine motility was restored to a normal level and the restoring effect was more pronounced in the combined treatment with trimebutine plus mosapride than treatment with trimebutine or mosapride alone. Furthermore, treatment with trimebutine plus mosapride signifi cantly decreased acute visceral pain which was not controlled by trimebutine or mosapride alone. These data suggest that combination therapy with trimebutine plus mosapride has a synergic effect on small and large intestine motility and visceral pain control in gastrointestinal disorders.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalBiomolecules and Therapeutics
Volume19
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • Gastrointestinal motility
  • Mosapride
  • Trimebutine

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