Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

Kyeong Lee; Jung S. Ryu; Yinglan Jin; Woncheol Kim; Navneet Kaur; Sang J. Chung; Yong Jin Jeon; Joon Tae Park; Ji S. Bang; Hong S. Lee; Tae Y. Kim; Jung J. Lee; Young Soo Hong

doi:10.1039/b713407j

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

Kyeong Lee, Jung S. Ryu, Yinglan Jin, Woncheol Kim, Navneet Kaur, Sang J. Chung, Yong Jin Jeon, Joon Tae Park, Ji S. Bang, Hong S. Lee, Tae Y. Kim, Jung J. Lee, Young Soo Hong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.

Original language	English
Pages (from-to)	340-348
Number of pages	9
Journal	Organic and Biomolecular Chemistry
Volume	6
Issue number	2
DOIs	https://doi.org/10.1039/b713407j
State	Published - 2008

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title = "Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites",

abstract = "A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.",

author = "Kyeong Lee and Ryu, {Jung S.} and Yinglan Jin and Woncheol Kim and Navneet Kaur and Chung, {Sang J.} and Jeon, {Yong Jin} and Park, {Joon Tae} and Bang, {Ji S.} and Lee, {Hong S.} and Kim, {Tae Y.} and Lee, {Jung J.} and Hong, {Young Soo}",

year = "2008",

doi = "10.1039/b713407j",

language = "English",

volume = "6",

pages = "340--348",

journal = "Organic and Biomolecular Chemistry",

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TY - JOUR

T1 - Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

AU - Lee, Kyeong

AU - Ryu, Jung S.

AU - Jin, Yinglan

AU - Kim, Woncheol

AU - Kaur, Navneet

AU - Chung, Sang J.

AU - Jeon, Yong Jin

AU - Park, Joon Tae

AU - Bang, Ji S.

AU - Lee, Hong S.

AU - Kim, Tae Y.

AU - Lee, Jung J.

AU - Hong, Young Soo

PY - 2008

Y1 - 2008

N2 - A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.

AB - A new series of geldanamycin derivatives were synthesized using a semi-synthetic approach involving genetically engineered biosynthetic intermediates. These analogues were then evaluated for anti-proliferation activity in human cancer cell lines, SK-Br3 and SK-Ov3. Most of the synthesized compounds exhibited potent in vitro anti-proliferation activity toward both cell lines. Such compounds potently inhibited the expression of the Hsp90 client protein ErbB2.

UR - http://www.scopus.com/inward/record.url?scp=37849038378&partnerID=8YFLogxK

U2 - 10.1039/b713407j

DO - 10.1039/b713407j

M3 - Article

C2 - 18175003

AN - SCOPUS:37849038378

SN - 1477-0520

VL - 6

SP - 340

EP - 348

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 2

ER -

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

Abstract

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