Synthesis and antitumor activity of 1-beta-4-selenoarabinofuranosyl cytosine (4'-seleno-ara-C)

Hankil Lee, Dilip K. Tosh, Won J.un Choi, Yu M.in Kim, Sang K.ook Lee, Lak S.hin Jeong

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

4-Seleno analogue of 1-beta-arabinofuranosyl cytosine (ara-C) was synthesized via 4'-selenouridine as a key intermediate, which was easily prepared from D-ribose. The arabino configuration was achieved by chemoselective ring opening of the 2,2'-anhydro-4'-selenouridine. The synthesized 4'-seleno-ara-C showed potent antitumor activity (IC(50) = 1.5 microM) against stomach cancer cells (SNU638).

Original languageEnglish
Pages (from-to)639-640
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
DOIs
StatePublished - 2008

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