Abstract
4-Seleno analogue of 1-beta-arabinofuranosyl cytosine (ara-C) was synthesized via 4'-selenouridine as a key intermediate, which was easily prepared from D-ribose. The arabino configuration was achieved by chemoselective ring opening of the 2,2'-anhydro-4'-selenouridine. The synthesized 4'-seleno-ara-C showed potent antitumor activity (IC(50) = 1.5 microM) against stomach cancer cells (SNU638).
Original language | English |
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Pages (from-to) | 639-640 |
Number of pages | 2 |
Journal | Nucleic acids symposium series (2004) |
Issue number | 52 |
DOIs | |
State | Published - 2008 |