Synthesis and antitumor activity of 1-beta-4-selenoarabinofuranosyl cytosine (4'-seleno-ara-C)

Hankil Lee; Dilip K. Tosh; Won J.un Choi; Yu M.in Kim; Sang K.ook Lee; Lak S.hin Jeong

doi:10.1093/nass/nrn323

Synthesis and antitumor activity of 1-beta-4-selenoarabinofuranosyl cytosine (4'-seleno-ara-C)

Hankil Lee
, Dilip K. Tosh
, Won J.un Choi
, Yu M.in Kim
, Sang K.ook Lee
, Lak S.hin Jeong

Department of Pharmacy

Ewha Womans University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

4-Seleno analogue of 1-beta-arabinofuranosyl cytosine (ara-C) was synthesized via 4'-selenouridine as a key intermediate, which was easily prepared from D-ribose. The arabino configuration was achieved by chemoselective ring opening of the 2,2'-anhydro-4'-selenouridine. The synthesized 4'-seleno-ara-C showed potent antitumor activity (IC(50) = 1.5 microM) against stomach cancer cells (SNU638).

Original language	English
Pages (from-to)	639-640
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	52
DOIs	https://doi.org/10.1093/nass/nrn323
State	Published - 2008

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10.1093/nass/nrn323

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title = "Synthesis and antitumor activity of 1-beta-4-selenoarabinofuranosyl cytosine (4'-seleno-ara-C)",

abstract = "4-Seleno analogue of 1-beta-arabinofuranosyl cytosine (ara-C) was synthesized via 4'-selenouridine as a key intermediate, which was easily prepared from D-ribose. The arabino configuration was achieved by chemoselective ring opening of the 2,2'-anhydro-4'-selenouridine. The synthesized 4'-seleno-ara-C showed potent antitumor activity (IC(50) = 1.5 microM) against stomach cancer cells (SNU638).",

author = "Hankil Lee and Tosh, \{Dilip K.\} and Choi, \{Won J.un\} and Kim, \{Yu M.in\} and Lee, \{Sang K.ook\} and Jeong, \{Lak S.hin\}",

year = "2008",

doi = "10.1093/nass/nrn323",

language = "English",

pages = "639--640",

journal = "Nucleic acids symposium series (2004)",

issn = "1746-8272",

publisher = "Oxford University Press",

number = "52",

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TY - JOUR

T1 - Synthesis and antitumor activity of 1-beta-4-selenoarabinofuranosyl cytosine (4'-seleno-ara-C)

AU - Lee, Hankil

AU - Tosh, Dilip K.

AU - Choi, Won J.un

AU - Kim, Yu M.in

AU - Lee, Sang K.ook

AU - Jeong, Lak S.hin

PY - 2008

Y1 - 2008

N2 - 4-Seleno analogue of 1-beta-arabinofuranosyl cytosine (ara-C) was synthesized via 4'-selenouridine as a key intermediate, which was easily prepared from D-ribose. The arabino configuration was achieved by chemoselective ring opening of the 2,2'-anhydro-4'-selenouridine. The synthesized 4'-seleno-ara-C showed potent antitumor activity (IC(50) = 1.5 microM) against stomach cancer cells (SNU638).

AB - 4-Seleno analogue of 1-beta-arabinofuranosyl cytosine (ara-C) was synthesized via 4'-selenouridine as a key intermediate, which was easily prepared from D-ribose. The arabino configuration was achieved by chemoselective ring opening of the 2,2'-anhydro-4'-selenouridine. The synthesized 4'-seleno-ara-C showed potent antitumor activity (IC(50) = 1.5 microM) against stomach cancer cells (SNU638).

UR - https://www.scopus.com/pages/publications/78649436192

U2 - 10.1093/nass/nrn323

DO - 10.1093/nass/nrn323

M3 - Article

C2 - 18776542

AN - SCOPUS:78649436192

SN - 1746-8272

SP - 639

EP - 640

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 52

ER -

Synthesis and antitumor activity of 1-beta-4-selenoarabinofuranosyl cytosine (4'-seleno-ara-C)

Abstract

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