Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines

Lak Shin Jeong; Long Xuan Zhao; Won Jun Choi; Shantanu Pal; Yeon Hee Park; Sang Kook Lee; Moon Woo Chun; Young B. Lee; Chang Ho Ahn; Hyung Ryong Moon

doi:10.1080/15257770701490852

Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines

Lak Shin Jeong, Long Xuan Zhao, Won Jun Choi, Shantanu Pal, Yeon Hee Park, Sang Kook Lee, Moon Woo Chun, Young B. Lee, Chang Ho Ahn, Hyung Ryong Moon

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.

Original language	English
Pages (from-to)	713-716
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	26
Issue number	6-7
DOIs	https://doi.org/10.1080/15257770701490852
State	Published - Jun 2007

Keywords

Antitumor
Electrophilic fluorination
Oxidative rearrangement; Mitsubobu condensation
Ring-closing metathesis

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10.1080/15257770701490852

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title = "Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines",

abstract = "Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.",

keywords = "Antitumor, Electrophilic fluorination, Oxidative rearrangement; Mitsubobu condensation, Ring-closing metathesis",

author = "Jeong, {Lak Shin} and Zhao, {Long Xuan} and Choi, {Won Jun} and Shantanu Pal and Park, {Yeon Hee} and Lee, {Sang Kook} and Chun, {Moon Woo} and Lee, {Young B.} and Ahn, {Chang Ho} and Moon, {Hyung Ryong}",

year = "2007",

month = jun,

doi = "10.1080/15257770701490852",

language = "English",

volume = "26",

pages = "713--716",

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T1 - Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines

AU - Jeong, Lak Shin

AU - Zhao, Long Xuan

AU - Choi, Won Jun

AU - Pal, Shantanu

AU - Park, Yeon Hee

AU - Lee, Sang Kook

AU - Chun, Moon Woo

AU - Lee, Young B.

AU - Ahn, Chang Ho

AU - Moon, Hyung Ryong

PY - 2007/6

Y1 - 2007/6

N2 - Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.

AB - Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.

KW - Antitumor

KW - Electrophilic fluorination

KW - Oxidative rearrangement; Mitsubobu condensation

KW - Ring-closing metathesis

UR - http://www.scopus.com/inward/record.url?scp=36949012733&partnerID=8YFLogxK

U2 - 10.1080/15257770701490852

DO - 10.1080/15257770701490852

M3 - Article

C2 - 18066886

AN - SCOPUS:36949012733

SN - 1525-7770

VL - 26

SP - 713

EP - 716

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 6-7

ER -

Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines

Abstract

Keywords

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