Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines

Lak Shin Jeong; Long Xuan Zhao; Won Jun Choi; Shantanu Pal; Yeon Hee Park; Sang Kook Lee; Moon Woo Chun; Young B. Lee; Chang Ho Ahn; Hyung Ryong Moon

doi:10.1080/15257770701490852

Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines

Lak Shin Jeong
, Long Xuan Zhao
, Won Jun Choi
, Shantanu Pal
, Yeon Hee Park
, Sang Kook Lee
, Moon Woo Chun
, Young B. Lee
, Chang Ho Ahn
, Hyung Ryong Moon

Department of Pharmacy

Ewha Womans University
Seoul National University
Rexahn Corporation
Pusan National University

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.

Original language	English
Pages (from-to)	713-716
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	26
Issue number	6-7
DOIs	https://doi.org/10.1080/15257770701490852
State	Published - Jun 2007

Keywords

Antitumor
Electrophilic fluorination
Oxidative rearrangement; Mitsubobu condensation
Ring-closing metathesis

Access to Document

10.1080/15257770701490852

Cite this

@article{50993407681149199fe53c98d0c3e47f,

title = "Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines",

abstract = "Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.",

keywords = "Antitumor, Electrophilic fluorination, Oxidative rearrangement; Mitsubobu condensation, Ring-closing metathesis",

author = "Jeong, \{Lak Shin\} and Zhao, \{Long Xuan\} and Choi, \{Won Jun\} and Shantanu Pal and Park, \{Yeon Hee\} and Lee, \{Sang Kook\} and Chun, \{Moon Woo\} and Lee, \{Young B.\} and Ahn, \{Chang Ho\} and Moon, \{Hyung Ryong\}",

year = "2007",

month = jun,

doi = "10.1080/15257770701490852",

language = "English",

volume = "26",

pages = "713--716",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

issn = "1525-7770",

publisher = "Taylor and Francis Ltd.",

number = "6-7",

}

TY - JOUR

T1 - Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines

AU - Jeong, Lak Shin

AU - Zhao, Long Xuan

AU - Choi, Won Jun

AU - Pal, Shantanu

AU - Park, Yeon Hee

AU - Lee, Sang Kook

AU - Chun, Moon Woo

AU - Lee, Young B.

AU - Ahn, Chang Ho

AU - Moon, Hyung Ryong

PY - 2007/6

Y1 - 2007/6

N2 - Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.

AB - Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from D-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.

KW - Antitumor

KW - Electrophilic fluorination

KW - Oxidative rearrangement; Mitsubobu condensation

KW - Ring-closing metathesis

UR - https://www.scopus.com/pages/publications/36949012733

U2 - 10.1080/15257770701490852

DO - 10.1080/15257770701490852

M3 - Article

C2 - 18066886

AN - SCOPUS:36949012733

SN - 1525-7770

VL - 26

SP - 713

EP - 716

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 6-7

ER -

Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this