Synthesis and biodistribution of cat's eye-shaped [57Co] CoO@SiO2 nanoshell aqueous colloids for single photon emission computed tomography (SPECT) imaging agent

Minjae Kwon, Jeong Hoon Park, Beom Su Jang, Hyun Jung

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

"Cat's eye"-shaped [57Co]CoO@SiO2 core-shell nanostructure was prepared by the reverse microemulsion method combined with radioisotope technique to investigate a potential imaging agent for a single photon emission computed tomography (SPECT) in nuclear medicine. The core cobalt oxide nanorods were obtained by thermal decomposition of Co-(oleate)2 precursor from radio isotope Co-57 containing cobalt chloride and sodium oleate. The SiO2 coating on the surface of the core cobalt oxide nanorods was produced by hydrolysis and a condensation reaction of tetraethylorthosilicate (TEOS) in the water phase of the reverse microemulsion system. In vivo test, micro SPECT image was acquired with nude mice after 30 min of intravenous injection of [57Co]CoO@SiO 2 core-shell nanostructure.

Original languageEnglish
Pages (from-to)2367-2370
Number of pages4
JournalBulletin of the Korean Chemical Society
Volume35
Issue number8
DOIs
StatePublished - 20 Aug 2014

Keywords

  • Cobalt
  • Imaging agents
  • Isotopic labeling
  • Nanoparticles
  • Silicate

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