Abstract
The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.
Original language | English |
---|---|
Pages (from-to) | 43-48 |
Number of pages | 6 |
Journal | Bulletin of the Korean Chemical Society |
Volume | 30 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2009 |
Keywords
- Coumarins
- Decursin
- Multidrug resistance
- P-glycoprotein
- Prantschimgin