Synthesis and biological evaluation of decursin, prantschimgin and their derivatives

Yan Xia, Kyung Hoon Min, Kyeong Lee

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalBulletin of the Korean Chemical Society
Volume30
Issue number1
DOIs
StatePublished - Jan 2009

Keywords

  • Coumarins
  • Decursin
  • Multidrug resistance
  • P-glycoprotein
  • Prantschimgin

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